The mixed block/event-related design.

The mixed block/event-related design.
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DOI:
10.1016/j.neuroimage.2011.09.084
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发表时间:
2012-08-15
期刊:
影响因子:
5.7
通讯作者:
Dubis, Joseph W.
Dubis, Joseph W.
中科院分区:
医学1区
文献类型:
--
作者:
Petersen, Steven E.;Dubis, Joseph W.

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神经影像研究开始使用模块设计和事件相关的设计实验。虽然这些功能磁共振成像设计类型提供了对大脑功能的许多见解,但忽略了可以教会我们其他元素的 BOLD 信号的组成部分。混合块/事件相关功能磁共振成像设计的开发可以更全面地表征非线性和时间敏感的神经元反应;例如,块和事件相关因素之间的相互作用,以及同时提取与试验和块转换相关的瞬时活动以及与任务级处理相关的持续活动。这篇综述追溯了混合块/事件相关设计的起源,从概念先驱到开创性论文,再到使用该方法的后续研究。该评论还评论了尝试使用混合块/事件相关设计时必须考虑的实验设计的各个方面。考虑到这些因素,混合块/事件相关设计可以更充分地利用 BOLD 信号,从而更深入地解释大脑区域在多个时间尺度上的功能。
Neuroimaging studies began using block design and event-related design experiments. While providing many insights into brain functions, these fMRI design types ignore components of the BOLD signal that can teach us additional elements. The development of the mixed block/event-related fMRI design allowed for a fuller characterization of nonlinear and time-sensitive neuronal responses; for example the interaction between block and event related factors and the simultaneous extraction of transient activity related to trials and block transitions and sustained activity related to task-level processing. This review traces the origins of the mixed block/event-related design from conceptual precursors to a seminal paper and on to subsequent studies using the method. The review also comments on aspects of the experimental design that must be considered when attempting to use the mixed block/event-related design. When taking into account these considerations, the mixed block/event-related design allows fuller utilization of the BOLD signal allowing deeper interpretation of how regions of the brain function on multiple timescales.
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