Longitudinal Assessment of Ellipsoid Zone Integrity, Subretinal Hyperreflective Material, and Subretinal Pigment Epithelium Disease in Neovascular Age-Related Macular Degeneration.
Longitudinal Assessment of Ellipsoid Zone Integrity, Subretinal Hyperreflective Material, and Subretinal Pigment Epithelium Disease in Neovascular Age-Related Macular Degeneration.
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DOI：
10.1016/j.oret.2021.02.012
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Srivastava SK
中科院分区：
文献类型：
--
作者：
Ehlers JP;Zahid R;Kaiser PK;Heier JS;Brown DM;Meng X;Reese J;Le TK;Lunasco L;Hu M;Srivastava SK
To longitudinally assess the effect of anti-vascular endothelial growth factor (VEGF) treatment on ellipsoid zone (EZ) integrity, subretinal hyperreflective material (SHRM), and the sub-retinal pigment epithelium (sub-RPE) compartment in eyes with neovascular age-related macular degeneration (nAMD). This study was a post hoc analysis of the OSPREY clinical trial, a prospective, double-masked, phase 2 study comparing brolucizumab 6 mg with aflibercept 2 mg over 56 weeks. Participants with treatment-naïve nAMD at the initiation of the trial were included in the analysis. Eyes were evaluated with spectral domain optical coherence tomography (SD-OCT) at 4-week intervals in the OSPREY trial (n=81). SD-OCT scans collected from each visit were automatically. segmented using a proprietary, machine learning enabled higher-order feature-extraction platform for retinal layer, SHRM, and sub-RPE boundary lines, which were evaluated and corrected as needed by masked trained graders. The current analysis focused only on subjects evaluated with Cirrus (Zeiss) platform, n=28). Outcome measures included change from baseline in EZ-RPE volume, EZ-RPE central subfield thickness (CST), total EZ attenuation, SHRM volume, SHRM CST, and total sub-RPE volume. The correlation between each of these measures and best corrected visual acuity (BCVA) at each visit was evaluated. EZ-RPE volume and EZ-RPE CST showed significant increases, and total EZ attenuation, SHRM volume, SHRM CST, and total sub-RPE volume showed significant decreases from baseline at each visit from Week 4–56 (P<.05 at each visit). EZ integrity measures and SHRM volume significantly correlated with BCVA at most visits (P<.05). No significant correlation was found between total sub-RPE volume and BCVA. EZ integrity, SHRM, and sub-RPE disease features in eyes with nAMD showed improvement as early as Week 4 of anti-VEGF treatment. EZ integrity measures and SHRM volume were predictors of visual acuity over the first year of treatment. EZ integrity improved, SHRM decreased, and total sub-RPE volume decreased with anti-VEGF treatment in eyes with nAMD. EZ integrity measures and SHRM volume correlated with visual acuity at most visits of the 56-week study.
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DOI：
10.1136/bjophthalmol-2015-307105
发表时间：
2016-03
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Itoh Y;Vasanji A;Ehlers JP
通讯作者：
Ehlers JP
影响因子：
3.7
作者：
Sasaki M;Kato Y;Fujinami K;Hirakata T;Tsunoda K;Watanabe K;Akiyama K;Noda T
通讯作者：
Noda T
影响因子：
4.4
作者：
Runkle AP;Kaiser PK;Srivastava SK;Schachat AP;Reese JL;Ehlers JP
通讯作者：
Ehlers JP
影响因子：
158.5
作者：
Brown, David M.;Kaiser, Peter K.;Schneider, Susan
通讯作者：
Schneider, Susan
影响因子：
13.7
作者：
Dugel, Pravin U.;Koh, Adrian;Holz, Frank G.
通讯作者：
Holz, Frank G.