Recruitment of N-Type Ca(2+) channels during LTP enhances low release efficacy of hippocampal CA1 perforant path synapses.
Recruitment of N-Type Ca(2+) channels during LTP enhances low release efficacy of hippocampal CA1 perforant path synapses.
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DOI：
10.1016/j.neuron.2009.07.013
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发表时间：
2009-08-13
期刊：
影响因子：
16.2
通讯作者：
Siegelbaum, Steven A.
中科院分区：
文献类型：
--
作者：
Ahmed, Mohsin S.;Siegelbaum, Steven A.
内嗅皮层分别通过穿支通路和Schaffer侧支突触向海马CA1区神经元提供直接和间接输入。使用突触小泡循环的双光子成像和电生理记录，我们发现穿透路径突触的递质释放效率低于Schaffer侧支输入。这种差异是由于突触前N型电压门控钙通道在Schaffer侧支对释放的贡献大于穿通径突触所致。长时程增强依赖于NMDA型受体和L电压门控钙通道的激活，通过增加N型通道对胞吐的贡献，增强了穿通通路突触释放的低效率。这代表了一种新的突触前机制，用于微调不同类型突触向共同突触后神经元的释放特性，并在突触长期可塑性期间调节突触功能。
The entorhinal cortex provides both direct and indirect inputs to hippocampal CA1 neurons through the perforant path and Schaffer collateral synapses, respectively. Using both two-photon imaging of synaptic vesicle cycling and electrophysiological recordings, we found that the efficacy of transmitter release at perforant path synapses is lower than at Schaffer collateral inputs. This difference is due to the greater contribution to release by presynaptic N-type voltage-gated Ca2+ channels at the Schaffer collateral than perforant path synapses. Induction of long-term potentiation that depends on activation of NMDA receptors and L-type voltage-gated Ca2+ channels enhances the low efficacy of release at perforant path synapses by increasing the contribution of N-type channels to exocytosis. This represents a novel presynaptic mechanism for fine-tuning release properties of distinct classes of synapses onto a common postsynaptic neuron and for regulating synaptic function during long-term synaptic plasticity.
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