Neural mechanisms of extinguishing drug and pleasant cue associations in human addiction: role of the VMPFC.
Neural mechanisms of extinguishing drug and pleasant cue associations in human addiction: role of the VMPFC.
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DOI：
10.1111/adb.12545
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发表时间：
2019-01
影响因子：
3.4
通讯作者：
Goldstein RZ
中科院分区：
文献类型：
--
作者：
Konova AB;Parvaz MA;Bernstein V;Zilverstand A;Moeller SJ;Delgado MR;Alia-Klein N;Goldstein RZ
药物成瘾中药物提示关联对消退的抵抗的神经生物学机制仍然未知。恐惧消退主要取决于腹内侧前额叶皮层（VMPFC）。在这里，我们测试了同一区域是否在非恐惧、药物和愉快提示关联的消除中发挥作用。 18 名长期可卡因使用者和 15 名匹配对照者完成了 3 次功能性 MRI 扫描。参与者首先学会将抽象提示（条件刺激，CS）与药物相关（CSD+）或令人愉快的（CSP+）图像联系起来。紧随其后的是消退，每个 CS 都在没有相应图像的情况下重复出现。 24 小时后，参与者接受了第二次相同的训练，以评估消退学习的保留情况。结果表明，与恐惧消退一样，非恐惧消退也依赖于 VMPFC。然而，VMPFC 中与灭绝相关的变化因提示效价和诊断而异。在对照组中，VMPFC 对 CSD+ 的激活（这对参与者来说是不愉快的）与恐惧消退一样逐渐增加，而对 CSP+ 的激活则减少，这与 VMPFC 在灵活价值更新中的更一般作用一致。为了支持消光保留中的特定作用，我们进一步观察了 VMPFC 激活和皮肤电导（条件反应的经典指标）之间的跨日关联。最后，可卡因使用者的两个 CS 都表现出 VMPFC 异常，在 CSD+ 的情况下，这与渴望相关。这些数据表明该群体在灭绝学习方面存在全球性缺陷，这可能会阻碍基于灭绝的治疗工作。更广泛地说，这些数据表明，当功能完整时，VMPFC 支持人类在不同环境下的灭绝学习。
The neurobiological mechanisms that underlie the resistance of drug cue associations to extinction in drug addiction remain unknown. Fear extinction critically depends on the ventromedial prefrontal cortex (VMPFC). Here we tested if this same region plays a role in extinction of non-fear, drug and pleasant cue associations. Eighteen chronic cocaine users and 15 matched controls completed three functional MRI scans. Participants first learned to associate an abstract cue (the conditioned stimulus, CS) with a drug-related (CSD+) or pleasant (CSP+) image. Extinction immediately followed where each CS was repeatedly presented without the corresponding image. Participants underwent a second identical session 24 h later to assess retention of extinction learning. Results showed that like fear extinction, non-fear based extinction relies on the VMPFC. However, extinction-related changes in the VMPFC differed by cue valence and diagnosis. In controls, VMPFC activation to the CSD+ (which was unpleasant for participants) gradually increased as in fear extinction, while it decreased to the CSP+, consistent with a more general role of the VMPFC in flexible value updating. Supporting a specific role in extinction retention, we further observed a cross-day association between VMPFC activation and skin conductance, a classic index of conditioned responses. Finally, cocaine users showed VMPFC abnormalities for both CSs, which in the case of the CSD+, correlated with craving. These data suggest a global deficit in extinction learning in this group that may hinder extinction-based treatment efforts. More broadly, these data show the VMPFC, when functionally intact, supports extinction learning in diverse contexts in humans.
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影响因子：
5.7
作者：
Bartra, Oscar;McGuire, Joseph T.;Kable, Joseph W.
通讯作者：
Kable, Joseph W.
DOI：
10.1523/jneurosci.2021-06.2006
发表时间：
2006-09-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kalisch R;Korenfeld E;Stephan KE;Weiskopf N;Seymour B;Dolan RJ
通讯作者：
Dolan RJ
DOI：
10.1111/j.1460-9568.2012.08211.x
发表时间：
2012-10
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Konova AB;Moeller SJ;Tomasi D;Parvaz MA;Alia-Klein N;Volkow ND;Goldstein RZ
通讯作者：
Goldstein RZ
影响因子：
5.3
作者：
McCracken, Clinton B.;Grace, Anthony A.
通讯作者：
Grace, Anthony A.
影响因子：
7.6
作者：
Kober, Hedy;Lacadie, Cheryl M.;Potenza, Marc N.
通讯作者：
Potenza, Marc N.