Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction.
Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction.
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DOI：
10.1111/j.1460-9568.2012.08211.x
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Goldstein RZ
中科院分区：
文献类型：
--
作者：
Konova AB;Moeller SJ;Tomasi D;Parvaz MA;Alia-Klein N;Volkow ND;Goldstein RZ
额纹状体系统的异常被认为是成瘾的病理生理学的核心，并可能是高度泛化的增强剂Money的不适应处理的基础。尽管在吸食可卡因上瘾的个体中观察到了额纹状体结构和功能的异常，但尚不清楚大脑结构中的个体差异如何与大脑功能相关，从而影响行为。我们的目标是检测慢性可卡因吸毒者和密切匹配的健康对照组的额纹状体结构和货币价值的神经加工。一项操纵不同水平金钱的奖励任务被用来分离与金钱价值相关的神经活动。灰质体积测量用于评估额纹状体结构。我们的结果表明，可卡因吸毒者在感觉运动纹状体(右壳核/苍白球)有异常的货币价值信号，这与对金钱的准确性调整呈负相关，且在使用越严重的个体中越明显。同时，在前额叶腹内侧皮质的功能和灰质体积上也观察到了组间差异；在可卡因吸毒者中，前者与纹状体对金钱的反应直接相关。这些结果为成瘾患者评估神经机制的异常提供了强有力的证据，并将这些功能异常与大脑结构的缺陷联系起来。此外，由于价值信号代表获得性联想，它们在纹状体感觉运动区域的异常处理可能表明，可卡因成瘾对联想学习不利。纹状体是与习惯形成密切相关的区域。
Abnormalities in frontostriatal systems are thought to be central to the pathophysiology of addiction, and may underlie maladaptive processing of the highly generalizable reinforcer, money. Although abnormal frontostriatal structure and function have been observed in individuals addicted to cocaine, it is less clear how individual variability in brain structure is associated with brain function to influence behavior. Our objective was to examine frontostriatal structure and neural processing of money value in chronic cocaine users and closely matched healthy controls. A reward task that manipulated different levels of money was used to isolate neural activity associated with money value. Gray matter volume measures were used to assess frontostriatal structure. Our results indicated that cocaine users had an abnormal money value signal in the sensorimotor striatum (right putamen/globus pallidus) which was negatively associated with accuracy adjustments to money and was more pronounced in individuals with more severe use. In parallel, group differences were also observed in both function and gray matter volume of the ventromedial prefrontal cortex; in the cocaine users, the former was directly associated with response to money in the striatum. These results provide strong evidence for abnormalities in the neural mechanisms of valuation in addiction and link these functional abnormalities with deficits in brain structure. In addition, as value signals represent acquired associations, their abnormal processing in the sensorimotor striatum, a region centrally implicated in habit formation, could signal disadvantageous associative learning in cocaine addiction.
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影响因子：
6
作者：
Chang, Linda;Alicata, Daniel;Volkow, Nora
通讯作者：
Volkow, Nora
影响因子：
10.6
作者：
Franklin, TR;Acton, PD;Childress, AR
通讯作者：
Childress, AR
DOI：
10.1523/jneurosci.5319-08.2009
发表时间：
2009-07-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bickel WK;Pitcock JA;Yi R;Angtuaco EJ
通讯作者：
Angtuaco EJ
影响因子：
--
作者：
Grant, BF;Hasin, DS;Dawson, DA
通讯作者：
Dawson, DA
影响因子：
5.3
作者：
Hare, Todd A.;O'Doherty, John;Rangel, Antonio
通讯作者：
Rangel, Antonio