Pyrimethanil and chlorpyrifos air concentrations and pregnant women's urinary metabolites in the Infants' Environmental Health Study (ISA), Costa Rica.
Pyrimethanil and chlorpyrifos air concentrations and pregnant women's urinary metabolites in the Infants' Environmental Health Study (ISA), Costa Rica.
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DOI：
10.1016/j.envint.2022.107328
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发表时间：
2022-08
影响因子：
11.8
通讯作者：
de Joode, Berna van Wendel
中科院分区：
文献类型：
--
作者：
Giffin, Andrew;Hoppin, Jane A.;Cordoba, Leonel;Solano-Diaz, Karla;Ruepert, Clemens;Penaloza-Castaneda, Jorge;Lindh, Christian;Reich, Brian J.;de Joode, Berna van Wendel
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只有少数研究比较了环境农药空气浓度与特定的尿液代谢物，以评估接触途径。因此，我们比较了哥斯达黎加马蒂纳县婴儿环境健康研究（伊萨）中孕妇空气中嘧霉胺和毒死蜱浓度与尿中4-羟基嘧霉胺（OHP，嘧霉胺的代谢物）和3，5，6-三氯-2-吡啶醇（TCPy，毒死蜱的代谢物）。在怀孕期间，我们从448名参加伊萨研究的妇女中获得了重复的尿液样本。我们外推嘧霉胺和毒死蜱浓度测量被动空气采样器（PAS）（n = 48，从12所学校），跨空间和时间使用贝叶斯时空模型。随后，我们比较了这些浓度与尿OHP和TCPy在915个样本，从448名妇女，使用单独的混合模型，并考虑几个协变量。空气中嘧霉胺（ng/m3）增加10%与OHP（μg/L）增加5.7%（95%置信区间（CI 4.6，6.8））相关。远离香蕉种植园的女性OHP较低：距离（米）每增加10%，OHP为-0.7%（95%CI-1.2，-0.3），每周吃米饭和豆类≥15次的女性OHP为-23%（95%CI-38，-4）。此外，空气中毒死蜱浓度每增加1纳克/立方米，三氯磷y浓度（微克/升）就会增加1.5%（95%可信区间0.2，2.8），从事农业工作的妇女往往会增加三氯磷y浓度（21%，95%可信区间−2，49）。贝叶斯时空模型可用于估计嘧霉胺和毒死蜱在空间和时间上的空气浓度。我们的研究结果表明，吸入嘧霉胺和毒死蜱是一个途径的环境暴露。PAS似乎是一个有用的技术，以监测环境当前使用的农药暴露。对于未来的研究，我们建议增加环境空气测量地点的数量，在同一个月内获得所有空气和尿液测量结果，最好也包括皮肤接触估计值。
Only few studies have compared environmental pesticide air concentrations with specific urinary metabolites to evaluate pathways of exposure. Therefore, we compared pyrimethanil and chlorpyrifos concentrations in air with urinary 4-hydroxypyrimethanil (OHP, metabolite of pyrimethanil) and 3,5,6-trichloro-2-pyridinol (TCPy, metabolite of chlorpyrifos) among pregnant women from the Infant’s Environmental Health Study (ISA) in Matina County, Costa Rica. During pregnancy, we obtained repeat urinary samples from 448 women enrolled in the ISA study. We extrapolated pyrimethanil and chlorpyrifos concentrations measured with passive air samplers (PAS) (n = 48, from 12 schools), across space and time using a Bayesian spatiotemporal model. We subsequently compared these concentrations with urinary OHP and TCPy in 915 samples from 448 women, using separate mixed models and considering several covariables. A 10% increase in air pyrimethanil (ng/m3) was associated with a 5.7% (95% confidence interval (CI 4.6, 6.8) increase in OHP (μg/L). Women living further from banana plantations had lower OHP: −0.7% (95% CI −1.2, −0.3) for each 10% increase in distance (meters) as well as women who ate rice and beans ≥15 times a week −23% (95% CI −38, −4). In addition, each 1 ng/m3 increase in chlorpyrifos in air was associated with a 1.5% (95% CI 0.2, 2.8) increase in TCPy (μg/L), and women working in agriculture tended to have increased TCPy (21%, 95% CI −2, 49). The Bayesian spatiotemporal models were useful to estimate pyrimethanil and chlorpyrifos air concentrations across space and time. Our results suggest inhalation of pyrimethanil and chlorpyrifos is a pathway of environmental exposure. PAS seems a useful technique to monitor environmental current-use pesticide exposures. For future studies, we recommend increasing the number of locations of environmental air measurements, obtaining all air and urine measurements during the same month, and, ideally, including dermal exposure estimates as well.
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DOI：
10.1038/s41370-020-0212-8
发表时间：
2020-07
影响因子：
4.5
作者：
Norén E;Lindh C;Rylander L;Glynn A;Axelsson J;Littorin M;Faniband M;Larsson E;Nielsen C
通讯作者：
Nielsen C
影响因子：
8.3
作者：
Cordoba Gamboa, Leonel;Solano Diaz, Karla;van Wendel de Joode, Berna
通讯作者：
van Wendel de Joode, Berna
影响因子：
10.4
作者：
Deziel NC;Freeman LE;Graubard BI;Jones RR;Hoppin JA;Thomas K;Hines CJ;Blair A;Sandler DP;Chen H;Lubin JH;Andreotti G;Alavanja MC;Friesen MC
通讯作者：
Friesen MC
影响因子：
2
作者：
Han, Don-Hee
通讯作者：
Han, Don-Hee
影响因子：
9.8
作者：
Hamsan, Hazwanee;Ho, Yu Bin;Karami, Ali
通讯作者：
Karami, Ali