Long-term alcohol intake and risk of endometrial cancer in the Nurses' Health Study, 1980-2010.
Long-term alcohol intake and risk of endometrial cancer in the Nurses' Health Study, 1980-2010.
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DOI：
10.1038/bjc.2014.257
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发表时间：
2014-07-08
影响因子：
8.8
通讯作者：
Giovannucci, E.
中科院分区：
文献类型：
--
作者：
Je, Y.;DeVivo, I.;Giovannucci, E.
以前的流行病学研究显示，酒精摄入量和子宫内膜癌风险之间的关联结果不一致。然而，大多数研究评估了癌症诊断后的酒精摄入量，或仅测量了基线时的酒精摄入量。我们在1980年对68067名年龄在34-59岁之间的女性参与者进行了护士健康研究，前瞻性地研究了酒精摄入量与子宫内膜癌风险之间的关系。酒精摄入量测量了几次验证饮食问卷。我们计算了累积平均酒精摄入量，以代表个体受试者的长期摄入量。使用考克斯比例风险模型，我们估计发病率比（RR）和95%置信区间（CI）的子宫内膜癌的风险后，同时控制几个危险因素。我们从1980年至2010年共确定了794例浸润性子宫内膜腺癌。我们发现饮酒者与不饮酒者之间存在负相关（多变量RR=0.81; 95%CI：0.68-0.96）。每天少量饮酒<5 g（每天饮酒1/2）的女性患子宫内膜癌的风险降低22%（多变量RR=0.78; 95%CI：0.66-0.94）。然而，更高的酒精摄入量并没有对子宫内膜癌提供额外的益处：每天5-14.9 g（101杯）、15-29.9 g（102杯）或1030 g（102杯）与0 g相比，多变量RR分别为0.88、0.83和0.78（95% CI：0.49-1.25）。饮酒者（每天饮酒1/2/3）的低风险似乎对肥胖女性更强，但没有发现体重指数的显著相互作用。这项研究提供了前瞻性证据，表明长期轻度饮酒（每天饮酒1/2/3）与子宫内膜癌风险之间存在负相关，但在该水平以上没有发现显著相关。
Previous epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only. We prospectively examined the association between alcohol intake and endometrial cancer risk in the Nurses' Health Study with 68 067 female participants aged 34–59 years in 1980. Alcohol intake was measured several times with validated dietary questionnaires. We calculated cumulative average alcohol intake to represent long-term intakes of individual subjects. Using Cox proportional hazards models, we estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) for endometrial cancer risk after controlling for several risk factors simultaneously. We identified a total of 794 invasive endometrial adenocarcinoma from 1980 to 2010. We found an inverse association among alcohol drinkers (multivariable RR=0.81; 95% CI: 0.68–0.96) compared with nondrinkers. Women with light alcohol intake of <5 g per day (∼half drink per day) had a 22% lower risk of endometrial cancer (multivariable RR=0.78; 95% CI: 0.66–0.94). Higher intake of alcohol, however, did not provide additional benefits against endometrial cancer: multivariable RRs for 5–14.9 g (∼1 drink), 15–29.9 g (∼2 drinks), or ⩾30 g (⩾2 drinks) versus 0 g per day were 0.88, 0.83, and 0.78 (95% CI: 0.49–1.25), respectively. The lower risk among drinkers (∼half drink per day) appeared to be stronger for obese women, but no significant interaction by body mass index was found. This study provides prospective evidence for an inverse association between light alcohol intake (∼half drink per day) in the long term and endometrial cancer risk, but above that level no significant association was found.
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DOI：
10.1158/1055-9965.epi-10-1089
发表时间：
2011-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cui X;Rosner B;Willett WC;Hankinson SE
通讯作者：
Hankinson SE
影响因子：
13.6
作者：
Jain, MG;Rohan, TE;Miller, AB
通讯作者：
Miller, AB
影响因子：
8.8
作者：
Dieli-Conwright, C. M.;Ma, H.;Lacey, J. V., Jr.;Henderson, K. D.;Neuhausen, S.;Horn-Ross, P. L.;Deapen, D.;Sullivan-Halley, J.;Bernstein, L.
通讯作者：
Bernstein, L.
影响因子：
2.3
作者：
Littman, AJ;Beresford, SAA;White, E
通讯作者：
White, E
DOI：
10.1016/0002-9378(93)90260-p
发表时间：
1993-11-01
影响因子：
9.8
作者：
AUSTIN, H;DREWS, C;PARTRIDGE, EE
通讯作者：
PARTRIDGE, EE