Smoked drug use in patients with TB is associated with higher bacterial burden.
Smoked drug use in patients with TB is associated with higher bacterial burden.
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DOI：
10.5588/ijtld.22.0650
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发表时间：
2023-06-01
期刊：
影响因子：
--
通讯作者：
Jacobson KR
中科院分区：
文献类型：
--
作者：
Myers B;Carney T;Rooney J;Malatesta S;Ragan EJ;White LF;Natcheva H;Bouton TC;Weber SE;Farhat M;McIlleron H;Theron D;Parry CDH;Horsburgh CR;Warren RM;Jacobson KR
吸食违禁药物可能会导致结核病进展更快或治疗延迟，但有关这一主题的研究还很少。我们研究了新开始接受药物敏感结核病 (DS-TB) 治疗的患者中吸烟药物使用与细菌负荷之间的关联。对南非西开普省 303 名接受 DS-TB 治疗的参与者的数据进行了分析。吸食毒品被定义为自我报告或经生物学验证的甲基苯丙胺、安眠酮和/或大麻的使用。比例风险和逻辑回归模型（根据年龄、性别、艾滋病毒状况和烟草使用进行调整）检查了吸毒与分枝杆菌培养阳性时间（TTP）、抗酸杆菌痰涂片阳性和肺空洞之间的关联。吸毒者 (PWSD) 占该群体的 54.8% (n = 166)。 PWSD 的 TTP 更快（风险比 1.48，95% CI 1.10–1.97；P = 0.008）。 PWSD 的涂片阳性率较高（OR 2.28，95% CI 1.22–4.34；P = 0.011）。吸食毒品（OR 1.08，95% CI 0.62–1.87；P = 0.799）与空化增加无关。 PWSD 在诊断时比不吸毒的人有更高的细菌负荷。在社区中对残疾人士进行结核病筛查可能有助于更早地与结核病治疗联系起来并减少社区传播。
Smoking of illicit drugs may lead to more rapid TB disease progression or late treatment presentation, yet research on this topic is scant. We examined the association between smoked drug use and bacterial burden among patients newly initiated on drug-susceptible TB (DS-TB) therapy. Data from 303 participants initiating DS-TB treatment in the Western Cape Province, South Africa, were analyzed. Smoked drug use was defined as self-reported or biologically verified methamphetamine, methaqualone and/or cannabis use. Proportional hazard and logistic regression models (adjusted for age, sex, HIV status and tobacco use) examined associations between smoked drug use and mycobacterial time to culture positivity (TTP), acid-fast bacilli sputum smear positivity and lung cavitation. People who smoked drugs (PWSD) comprised 54.8% (n = 166) of the cohort. TTP was faster for PWSD (hazard ratio 1.48, 95% CI 1.10–1.97; P = 0.008). Smear positivity was higher among PWSD (OR 2.28, 95% CI 1.22–4.34; P = 0.011). Smoked drug use (OR 1.08, 95% CI 0.62–1.87; P = 0.799) was not associated with increased cavitation. PWSD had a higher bacterial burden at diagnosis than those who do not smoke drugs. Screening for TB among PWSD in the community may facilitate earlier linkage to TB treatment and reduce community transmission.
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南非15岁以上的人的危险，有害或依赖的酒精使用和吸毒的患病率和相关性：2017年全国调查的结果。
DOI：
10.4102/phcfm.v13i1.2847
发表时间：
2021-03-23
影响因子：
2
作者：
Pengpid S;Peltzer K;Ramlagan S
通讯作者：
Ramlagan S
影响因子：
4.2
作者：
Meade, Christina S.;Towe, Sheri L.;Watt, Melissa H.;Lion, Ryan R.;Myers, Bronwyn;Skinner, Donald;Kimani, Stephen;Pieterse, Desiree
通讯作者：
Pieterse, Desiree
DOI：
10.1086/594126
发表时间：
2009-01-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Deiss RG;Rodwell TC;Garfein RS
通讯作者：
Garfein RS
影响因子：
10
作者：
Romanowski, Kamila;Balshaw, Robert F.;Johnston, James C.
通讯作者：
Johnston, James C.
影响因子：
3.7
作者：
Minja LT;Hella J;Mbwambo J;Nyandindi C;Omary US;Levira F;Mpagama S;Shimwela M;Okuma J;Gagneux S;Bruce RD;Reither K
通讯作者：
Reither K