Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments.
Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments.
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DOI：
10.1111/nyas.12742
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发表时间：
2015-05
影响因子：
5.2
通讯作者：
Cook IA
中科院分区：
文献类型：
--
作者：
Leuchter AF;Hunter AM;Krantz DE;Cook IA
严重抑郁障碍(MDD)的治疗在生物复杂性的不同等级水平上发挥作用，从单个突触到整个大脑。抗抑郁药物作用的理论传统上侧重于细胞间相互作用和突触神经传递的水平。然而，最近的证据表明，神经网络中同步电活动的调制是抗抑郁药物治疗的常见效果，不仅包括药物治疗，还包括神经调制治疗，如重复的经颅磁刺激。在特定频段内振荡网络活动的同步化被认为是神经发育和学习过程的基础，也可能在抗抑郁治疗的作用机制中发挥重要作用。本文综述了神经可塑性和振荡同步性之间关系的研究现状，认为振荡同步性可能有助于介导与神经发育、学习和记忆相关的神经可塑性改变，以及药物和神经调节治疗对MDD的治疗。我们假设药物和神经调节治疗可能对神经元放电的速度和模式有相关的影响，这些影响是抗抑郁药物疗效的基础。阐明振荡同步性可能与神经可塑性有关的机制可能有助于加强MDD的治疗策略。
Treatments for major depressive disorder (MDD) act at different hierarchical levels of biological complexity, ranging from the individual synapse to the brain as a whole. Theories of antidepressant medication action traditionally have focused on the level of cell-to-cell interaction and synaptic neurotransmission. However, recent evidence suggests that modulation of synchronized electrical activity in neuronal networks is a common effect of antidepressant treatments, including not only medications, but also neuromodulatory treatments such as repetitive transcranial magnetic stimulation. Synchronization of oscillatory network activity in particular frequency bands has been proposed to underlie neurodevelopmental and learning processes, and also may be important in the mechanism of action of antidepressant treatments. Here, we review current research on the relationship between neuroplasticity and oscillatory synchrony, which suggests that oscillatory synchrony may help mediate neuroplastic changes related to neurodevelopment, learning, and memory, as well as medication and neuromodulatory treatment for MDD. We hypothesize that medication and neuromodulation treatments may have related effects on the rate and pattern of neuronal firing, and that these effects underlie antidepressant efficacy. Elucidating the mechanisms through which oscillatory synchrony may be related to neuroplasticity could lead to enhanced treatment strategies for MDD.
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影响因子：
10.6
作者：
Chowdhury, Golam M. I.;Behar, Kevin L.;Cho, William;Thomas, Monique A.;Rothman, Douglas L.;Sanacora, Gerard
通讯作者：
Sanacora, Gerard
影响因子：
5.7
作者：
Ch'ng TH;Martin KC
通讯作者：
Martin KC
影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
DOI：
10.1073/pnas.0912973107
发表时间：
2010-04-13
影响因子：
11.1
作者：
Chen, Lulu Y.;Rex, Christopher S.;Gall, Christine M.
通讯作者：
Gall, Christine M.