Leveraging the human microbiota to target bacterial respiratory pathogens: new paths toward an expanded antimicrobial armamentarium.
Leveraging the human microbiota to target bacterial respiratory pathogens: new paths toward an expanded antimicrobial armamentarium.
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急性呼吸道感染是生命周期中最常见的感染，也是全球儿童死亡的主要传染性原因。细菌性呼吸道感染通常用抗生素治疗，几乎所有抗生素都来自微生物天然产物。不幸的是，抗药性细菌是呼吸道感染的一个越来越常见的原因，并且很少有针对这些病原体的新抗生素正在开发中。在Stubbendieck等人的文章中，作者鉴定了证明在体外和离体生长抑制呼吸道致病菌卡他莫拉氏菌的Rothia属物种。作者提出的实验表明，这种活性至少部分是通过分泌一种新的肽聚糖内肽酶介导的，这种肽聚糖内肽酶靶向M。粘膜炎细胞壁。在这篇评论中，我们在抗菌素耐药性的紧迫威胁的背景下讨论了这些发现，并强调了人类呼吸道微生物群作为新型生物治疗药物来源的前景。
Acute respiratory infections are the most frequent infections across the lifespan and are the leading infectious cause of death among children globally. Bacterial respiratory infections are routinely treated with antibiotics, nearly all of which are derived from microbial natural products. Unfortunately, antibiotic-resistant bacteria are an increasingly frequent cause of respiratory infections, and there are few new antibiotics in development that target these pathogens. In the article by Stubbendieck et al., the authors identified Rothia species that demonstrate in vitro and ex vivo growth inhibition of the respiratory pathobiont Moraxella catarrhalis. The authors present experiments suggesting that this activity is mediated at least in part through the secretion of a novel peptidoglycan endopeptidase that targets the M. catarrhalis cell wall. In this commentary, we discuss these findings in the context of the urgent threat of antimicrobial resistance and highlight the promise of the human respiratory microbiota as a source of novel biotherapeutics.
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影响因子：
8
作者：
Kaur, Ravinder;Morris, Matthew;Pichichero, Michael E.
通讯作者：
Pichichero, Michael E.
影响因子：
11.8
作者：
Murphy, Timothy F.;Parameswaran, G. Iyer
通讯作者：
Parameswaran, G. Iyer
影响因子：
5.5
作者：
Bosch, Astrid A. T. M.;van Houten, Marlies A.;Sanders, Elisabeth A. M.
通讯作者：
Sanders, Elisabeth A. M.
DOI：
10.1016/s0140-6736(21)02724-0
发表时间：
2022-02-12
期刊：
Lancet (London, England)
影响因子：
--
作者：
Antimicrobial Resistance Collaborators
通讯作者：
Antimicrobial Resistance Collaborators
影响因子：
6.4
作者：
Stubbendieck, Reed M.;Dissanayake, Eishika;Burnham, Peter M.;Zelasko, Susan E.;Temkin, Mia I.;Wisdorf, Sydney S.;Vrtis, Rose F.;Gern, James E.;Currie, Cameron R.
通讯作者：
Currie, Cameron R.