Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types.
Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types.
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DOI：
10.1016/j.immuni.2011.08.007
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发表时间：
2011-08-26
期刊：
影响因子：
32.4
通讯作者：
Zhao K
中科院分区：
文献类型：
--
作者：
Wei G;Abraham BJ;Yagi R;Jothi R;Cui K;Sharma S;Narlikar L;Northrup DL;Tang Q;Paul WE;Zhu J;Zhao K
转录因子GATA 3在T细胞发育和辅助性T细胞2（Th 2）分化过程中起着重要作用。为了了解GATA 3介导的基因调控，我们在10个明确的发育和效应T淋巴细胞谱系中鉴定了全基因组GATA 3结合位点。在胸腺中，GATA 3直接调节许多关键因子，包括Th-POK、Notch 1和T细胞受体亚基。在外周，GATA 3诱导了大量的Th 2细胞特异性以及Th 2细胞非特异性基因，包括几个转录因子。我们的数据还表明，GATA 3调节许多靶基因的活性和抑制性组蛋白修饰在其附近的GATA 3结合位点的调控元件。总体而言，虽然GATA 3结合在各种T细胞谱系中表现出共享和细胞特异性模式，但许多基因以细胞类型特异性方式被GATA 3正向或负向调节，表明GATA 3介导的基因调节强烈依赖于不同T细胞中存在的辅因子。
The transcription factor GATA3 plays an essential role during T cell development and T helper 2 (Th2) cell differentiation. To understand GATA3-mediated gene regulation, we identified genome-wide GATA3 binding sites in ten well-defined developmental and effector T lymphocyte lineages. In the thymus, GATA3 directly regulated many critical factors, including Th-POK, Notch1 and T cell receptor subunits. In the periphery, GATA3 induced a large number of Th2 cell-specific as well as Th2 cell non-specific genes, including several transcription factors. Our data also indicate that GATA3 regulates both active and repressive histone modifications of many target genes at their regulatory elements near GATA3 binding sites. Overall, although GATA3 binding exhibited both shared and cell-specific patterns among various T cell lineages, many genes were either positively or negatively regulated by GATA3 in a cell type-specific manner, suggesting that GATA3-mediated gene regulation depends strongly on co-factors existing in different T cells.
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影响因子：
16
作者：
Fujiwara T;O'Geen H;Keles S;Blahnik K;Linnemann AK;Kang YA;Choi K;Farnham PJ;Bresnick EH
通讯作者：
Bresnick EH
影响因子：
10.5
作者：
Roh, TY;Cuddapah, S;Zhao, K
通讯作者：
Zhao, K
影响因子：
64.8
作者：
He, X;He, X;Kappes, DJ
通讯作者：
Kappes, DJ
DOI：
10.1084/jem.184.3.1137
发表时间：
1996-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hattori N;Kawamoto H;Fujimoto S;Kuno K;Katsura Y
通讯作者：
Katsura Y
DOI：
10.1073/pnas.0909357106
发表时间：
2009-10-20
影响因子：
11.1
作者：
Jenner, Richard G.;Townsend, Michael J.;Lord, Graham M.
通讯作者：
Lord, Graham M.