Assessment of spatial memory in mice.
Assessment of spatial memory in mice.
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DOI：
10.1016/j.lfs.2010.09.004
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发表时间：
2010-10-23
期刊：
影响因子：
6.1
通讯作者：
Brown-Borg H
中科院分区：
文献类型：
--
作者：
Sharma S;Rakoczy S;Brown-Borg H
医疗保健的改善大大延长了美国人的寿命。现在的重点正在从身体健康转向改善老年人的心理健康或维持认知功能。众所周知，老年人患有认知障碍，即使没有神经变性，也是“正常衰老”的一部分。这种“年龄相关性记忆障碍”（AAMI）可能对个人和社会的社会和经济生活产生破坏性影响。科学家们一直在尝试寻找防止与衰老有关的记忆丧失的方法。在这些实验中涉及的主要因素是使用动物模型来评估基于空间记忆的空间记忆。这篇综述描述了不同类型的记忆，包括易受衰老影响的基于大脑的记忆。详细概述了用于评估空间记忆的各种行为范式，包括T-迷宫，径向迷宫，Morris水迷宫，巴恩斯迷宫和其他。该综述还描述了海马体记忆的分子基础，称为“长时程增强”。的优点和局限性的行为模型在评估记忆和链接到长时程增强进行了讨论。这篇综述有助于研究者选择合适的方法来评估小鼠的空间记忆。
Improvements in health care have greatly increased life span in the United States. The focus is now shifting from physical well-being to improvement in mental well-being or maintenance of cognitive function in old age. It is known that elderly people suffer from cognitive impairment, even without neurodegeneration, as a part of ‘normal aging’. This ‘age-associated memory impairment’ (AAMI), can have a devastating impact on the social and economic life of an individual as well as the society. Scientists have been experimenting to find methods to prevent the memory loss associated with aging. The major factor involved in these experiments is the use of animal models to assess hippocampal-based spatial memory. This review describes the different types of memory including hippocampal-based memory that is vulnerable to aging. A detailed overview of various behavioral paradigms used to assess spatial memory including the T-maze, radial maze, Morris water maze, Barnes maze and others is presented. The review also describes the molecular basis of memory in hippocampus called as ‘long-term potentiation’. The advantages and limitations of the behavioral models in assessing memory and the link to the long-term potentiation are discussed. This review should assist investigators in choosing suitable methods to assess spatial memory in mice.
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影响因子：
64.8
作者：
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通讯作者：
BENARI, Y
影响因子：
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