Peer influences on drug self-administration: social facilitation and social inhibition of cocaine intake in male rats.
Peer influences on drug self-administration: social facilitation and social inhibition of cocaine intake in male rats.
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DOI：
10.1007/s00213-012-2737-6
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发表时间：
2012-11
影响因子：
3.4
通讯作者：
Smith, Mark A.
中科院分区：
文献类型：
--
作者：
Smith, Mark A.
关键词：
静脉注射药物自我给药的动物模型面临的一个问题，特别是那些检验社会操纵的动物模型，是在测试期间必须将受试者从家庭环境中移出并与笼子分开。这代表了动物模型的局限性，因为它无法捕捉到经常发生吸毒的复杂社会环境。本研究的目的是在隔离和社会饲养的大鼠中检查静脉注射可卡因的自我给药，并注意到社会饲养的受试者每天24小时生活在一起，包括每天的自我给药期间。作为次要目的，该研究检查了一个也自己服用可卡因的同伴与一个没有可卡因的同伴的影响。在断奶时获得雄性大鼠，在隔离或成对饲养条件下饲养6周。然后给大鼠植入静脉导管，并将其转移到定制的操作性条件反射室中，作为研究剩余时间的家庭笼子。对于一些群居的实验对象，两只大鼠同时获得可卡因；对于其他老鼠，这对老鼠中只有一只能接触到可卡因。如果两只老鼠都能接触到可卡因，那么在社会饲养的老鼠中，可卡因的自我管理就会更容易；然而，如果这对老鼠中只有一只能接触到可卡因，那么可卡因的自我给药就会受到抑制。这些数据表明同伴的自我给药行为，而不仅仅是同伴的存在，决定了社会接触是否促进或抑制可卡因的自我给药。
One problem facing animal models of intravenous drug self-administration, particularly those examining social manipulations, is that subjects must be removed from the home environment and separated from cagemates during testing. This represents a limitation of animal models, because it fails to capture the complex social environments in which drug use often occurs. The aim of this study was to examine intravenous cocaine self-administration in isolated and socially housed rats, with the caveat that the socially housed subjects lived together 24 hr/day, including during daily self-administration sessions. As a secondary aim, the study examined the impact of a companion that also self-administered cocaine versus a companion without access to cocaine. Male rats were obtained at weaning and reared in isolated or pair-housed conditions for 6 weeks. Rats were then implanted with intravenous catheters and transferred to custom-built operant conditioning chambers that served as home cages for the remainder of the study. For some socially housed subjects, both rats had simultaneous access to cocaine; for others, only one rat of the pair had access to cocaine. Cocaine self-administration was facilitated in socially housed rats if both members of the pair had access to cocaine; however, cocaine self-administration was inhibited if only one rat of the pair had access to cocaine. These data indicate that the self-administration behavior of a peer, not merely the presence of a peer, determines whether cocaine self-administration is facilitated or inhibited by social contact.
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影响因子：
56.9
作者：
JOHN, ER;CHESLER, P;VICTOR, I
通讯作者：
VICTOR, I
DOI：
10.1124/jpet.108.139196
发表时间：
2008-09-01
影响因子：
3.5
作者：
Cooper, Ziva D.;Truong, Yen Nhu-Thi;Woods, James H.
通讯作者：
Woods, James H.
影响因子：
2.3
作者：
Gipson, Cassandra D.;Yates, Justin R.;Bardo, Michael T.
通讯作者：
Bardo, Michael T.
影响因子：
1.4
作者：
Herbert, MJ;Harsh, CM
通讯作者：
Harsh, CM
影响因子：
2.9
作者：
Peartree NA;Hood LE;Thiel KJ;Sanabria F;Pentkowski NS;Chandler KN;Neisewander JL
通讯作者：
Neisewander JL