Colostral antibody-mediated and cell-mediated immunity contributes to innate and antigen-specific immunity in piglets.
Colostral antibody-mediated and cell-mediated immunity contributes to innate and antigen-specific immunity in piglets.
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DOI：
10.1016/j.dci.2013.11.005
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发表时间：
2014-03
影响因子：
2.9
通讯作者：
Molitor, Thomas W.
中科院分区：
文献类型：
--
作者：
Bandrick, Meggan;Ariza-Nieto, Claudia;Baidoo, Samuel K.;Molitor, Thomas W.
免疫球蛋白和免疫细胞是造影素免疫细胞的关键成分，但是，它们在新生儿中的转移和功能，尤其是材料淋巴细胞，尚不清楚细胞介导的细胞和抗体介导（AS）评估哺乳以研究CD4，CD8和γδ淋巴细胞中母体免疫的转移和功能。仔猪PS并具有独特的T淋巴细胞谱。初乳和随后的淋巴细胞转移到新生儿中，但是对乳腺癌的自然杀手活性和抗原特异性的评估是统一的。增殖表明，结肠细胞能够影响新生儿猪的先天和特异性免疫反应。
Immunoglobulins and immune cells are critical components of colostral immunity; however, their transfer to and function in the neonate, especially maternal lymphocytes, is unclear. Cell-mediated and antibody-mediated immunity in sow blood and colostrum and piglet blood before (PS) and after (AS) suckling were assessed to investigate transfer and function of maternal immunity in the piglet. CD4, CD8, and γδ lymphocytes were found in sow blood and colostrum and piglet blood PS and AS; each had a unique T lymphocyte profile. Immunoglobulins were detected in sow blood, colostrum, and in piglet blood AS; the immunoglobulin profile of piglet serum AS mimicked that of sow serum. These results suggest selectivity in lymphocyte concentration into colostrum and subsequent lymphocyte transfer into the neonate, but that immunoglobulin transfer is unimpeded. Assessment of colostral natural killer activity and antigen-specific proliferation revealed that colostral cells are capable of influencing the innate and specific immune response of neonatal pigs.
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DOI：
10.1016/0005-2795(71)90181-4
发表时间：
1971-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
CURTIS, J;BOURNE, FJ
通讯作者：
BOURNE, FJ
影响因子：
5.1
作者：
OGRA, SS;OGRA, PL
通讯作者：
OGRA, PL
影响因子：
1.8
作者：
DILLENDER, MJ;LUNNEY, JK
通讯作者：
LUNNEY, JK
影响因子：
1.8
作者：
HARP, JA;MOON, HW
通讯作者：
MOON, HW
影响因子：
2.4
作者：
KLOBASA, F;WERHAHN, E;BUTLER, JE
通讯作者：
BUTLER, JE