Retinal Optical Coherence Tomography
Retinal Optical Coherence Tomography
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视网膜光学相干断层扫描
DOI：
10.1007/978-3-540-77550-8_32
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发表时间：
2008
影响因子：
13.8
通讯作者：
J. Fujimoto
中科院分区：
文献类型：
--
作者：
W. Drexler;J. Fujimoto
眼睛本质上是透明的，光的传输只有最小的光学衰减和散射，为前段和视网膜提供了方便的光学通道。因此，光学相干断层扫描（OCT）在眼科尤其是视网膜成像领域的应用不仅是最早的，而且是最成功的。本章重点介绍了视网膜成像OCT技术的发展。OCT显著提高了早期诊断、了解视网膜疾病发病机制以及监测疾病进展和对治疗的反应的潜力。超宽带光源和高速检测技术的发展使眼科OCT成像性能得到了显著改善，展示了三维超高分辨率OCT （3D UHR OCT）对活体视网膜进行无创光学活检的潜力，即，活体视网膜显微结构的可视化，视网膜内的原位形态接近传统组织病理学的分辨率。轴向分辨率和速度的显著提高不仅可以实现视网膜体积的三维绘制，还可以实现高清晰度，2D断层摄影，所有主要视网膜层的地形厚度图以及病理视网膜内变化的体积量化。这些OCT技术的进步也成功地应用于几种视网膜病变的动物模型。在替代波长（例如约1,050 nm）发射的光源的发展，不仅使三维OCT成像具有增强的脉络膜可视化，而且由于减少了该波长区域的散射损失，也提高了白内障患者的OCT性能。自适应光学采用可变形镜技术，具有独特的高笔画来纠正高阶眼像差，特别设计的光学补偿人眼色差，结合3D UHR OCT，最近实现了胞内分辨率视网膜成像。
The eye is essentially transparent, transmitting light with only minimal optical attenuation and scattering, providing easy optical access to the anterior segment as well as the retina. For this reason, ophthalmic and especially retinal imaging has been not only the first, but also most successful clinical application for optical coherence tomography (OCT). This chapter focuses on the development of OCT technology for retinal imaging. OCT has significantly improved the potential for early diagnosis, understanding of retinal disease pathogenesis as well as monitoring disease progression and response to therapy. Development of ultrabroad bandwidth light sources and high speed detection techniques have enabled significant improvements in ophthalmic OCT imaging performance, demonstrating the potential of three-dimensional, ultrahigh resolution OCT (3D UHR OCT) to perform noninvasive optical biopsy of the living human retina, i.e., thein vivovisualization of microstructural, intraretinal morphology in situ approaching the resolution of conventional histopathology. Significant improvements in axial resolutionandspeed not only enable three-dimensional rendering of retinal volumes, but also high definition, 2D tomograms, topographic thickness maps of all major intraretinal layers as well as volumetric quantification of pathologic intraretinal changes. These advances in OCT technology have also been successfully applied in several animal models of retinal pathologies. The development of light sources emitting at alternative wavelengths, e.g., around ∼l,050 nm, not only enabled three-dimensional OCT imaging with enhanced choroidal visualization, but also improved OCT performance in cataract patients because of reduced scattering losses in this wavelength region. Adaptive optics using deformable mirror technology, with unique high stroke to correct higher order ocular aberrations, with specially designed optics to compensate chromatic aberration of the human eye, in combination with 3D UHR OCT, recently enabledin vivocellular resolution retinal imaging.
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影响因子：
4.4
作者：
C. Bowd;L. Zangwill;C. Berry;E. Blumenthal;Cristiana Vasile;César A. Sánchez-Galeana;C. F. Bosworth-
通讯作者：
C. Bowd;L. Zangwill;C. Berry;E. Blumenthal;Cristiana Vasile;César A. Sánchez-Galeana;C. F. Bosworth-
影响因子：
13.7
作者：
Ko, TH;Fujimoto, JG;Duker, JS
通讯作者：
Duker, JS
影响因子：
3.6
作者：
Nassif, N;Cense, B;de Boer, JF
通讯作者：
de Boer, JF
影响因子：
3.8
作者：
Zhang, Yan;Cense, Barry;Miller, Donald T.
通讯作者：
Miller, Donald T.
影响因子：
4.2
作者：
HEE, MR;PULIAFITO, CA;FUJIMOTO, JG
通讯作者：
FUJIMOTO, JG