Higher Serum Neuropeptide Y Levels Are Associated with Metabolically Unhealthy Obesity in Obese Chinese Adults: A Cross-Sectional Study
Higher Serum Neuropeptide Y Levels Are Associated with Metabolically Unhealthy Obesity in Obese Chinese Adults: A Cross-Sectional Study
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较高的血清神经肽 Y 水平与中国肥胖成人代谢不健康的肥胖相关：一项横断面研究
DOI：
10.1155/2020/7903140
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发表时间：
2020-08
影响因子：
4.6
通讯作者：
Zhou Hou-De
中科院分区：
文献类型：
--
作者：
Tang Hao-Neng;Xiao Fen;Chen Ya-Ru;Zhuang Si-Qi;Guo Yue;Wu Hui-Xuan;Zhou Hou-De
目的神经肽Y（NPY）是一种已知能引起食欲亢进的促食欲肽，与肥胖的发生和发展有关。然而，肥胖表型（包括代谢不健康肥胖（MUO）表型和代谢健康肥胖（MHO）表型）血清NPY水平分布的差异以及NPY与MUO表型的关联尚未明确确定。因此，我们确定了中国肥胖成人血清 NPY 水平与 MUO 表型的关联。方法对湖南省400名在湘雅二医院进行健康检查的肥胖成年人进行横断面研究，最终纳入研究164例，分为MHO组和MUO组。检查血清 NPY 水平；进行单变量和多变量分析以及平滑曲线拟合分析来测量 NPY 血清水平与 MUO 表型的关联。结果 与MHO组相比，MUO组血清NPY水平显着升高（（667.69±292.90）pg/mL vs.（478.89±145.53）pg/mL，p < 0.001）。发现血清 NPY 水平与 MUO 之间存在阈值和非线性关联 (p = 0.001)。当血清 NPY 水平超过转折点 (471.5 pg/mL) 时，在调整混杂因素后，NPY 血清水平每增加 10 pg/mL 与 MUO 表型比值比增加 18% 显着相关 (OR: 1.18, 95% CI: 1.07–1.29, p = 0.0007)。结论 中国肥胖成人中较高的 NPY 血清水平与 MUO 表型呈正相关。
Objective Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity (MHO) phenotype) and the association of NPY with MUO phenotype have not been unequivocally established. We therefore determined associations of serum NPY levels with MUO phenotype in obese Chinese adults. Methods A cross-sectional study was conducted from 400 obese adults in Hunan province, who underwent a health examination in the Second Xiangya Hospital, and 164 participants were finally enrolled in the study and divided into MHO and MUO groups. Serum NPY levels were examined; univariate and multivariate analyses as well as smooth curve fitting analyses were conducted to measure the association of NPY serum levels with the MUO phenotype. Results Serum NPY levels were significantly elevated in the MUO group compared with the MHO group ((667.69 ± 292.90) pg/mL vs. (478.89 ± 145.53) pg/mL, p < 0.001). A threshold and nonlinear association between serum NPY levels and MUO was found (p = 0.001). When serum NPY levels exceeded the turning point (471.5 pg/mL), each 10 pg/mL increment in the NPY serum level was significantly associated with an 18% increased odds ratio of MUO phenotype (OR: 1.18, 95% CI: 1.07–1.29, p = 0.0007) after adjusted for confounders. Conclusions Higher NPY serum levels were positively correlated with MUO phenotype in obese Chinese adults.
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