Cellular-level surgery using nano robots.

Cellular-level surgery using nano robots.
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DOI:
10.1177/2211068212460665
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发表时间:
2012-12
期刊:
Journal of laboratory automation
影响因子:
--
通讯作者:
Lai KW
Lai KW
中科院分区:
其他
文献类型:
--
作者:
Song B;Yang R;Xi N;Patterson KC;Qu C;Lai KW

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原子力显微镜(AFM)是一种用于研究纳米世界的常用仪器。AFM天生适用于对生物样本进行成像以及测量其机械性能。在本文中,我们提出了一种基于AFM的纳米机器人的新概念,它可应用于对生物样本进行细胞层面的手术。这种纳米机器人具有成像、操作、表征机械性能以及追踪等多种功能。此外,针尖功能化技术使纳米机器人具备在局部精确给药的能力。因此,这种纳米机器人可用于对生物样本(如细胞和细菌)进行复杂的纳米手术。而且,为了提供一个用户友好的界面,该纳米机器人中的软件提供一种“视频化”的视觉反馈,用于监测样本表面的动态变化。纳米手术的操作以及对手术结果的观察可同时实现。这种纳米机器人可轻松与其他模块集成,这些模块在表征样本的其他特性(如局部电导和电容)方面具有潜在应用。
The atomic force microscope (AFM) is a popular instrument for studying the nano world. AFM is naturally suitable for imaging living samples and measuring mechanical properties. In this article, we propose a new concept of an AFM-based nano robot that can be applied for cellular-level surgery on living samples. The nano robot has multiple functions of imaging, manipulation, characterizing mechanical properties, and tracking. In addition, the technique of tip functionalization allows the nano robot the ability for precisely delivering a drug locally. Therefore, the nano robot can be used for conducting complicated nano surgery on living samples, such as cells and bacteria. Moreover, to provide a user-friendly interface, the software in this nano robot provides a “videolized” visual feedback for monitoring the dynamic changes on the sample surface. Both the operation of nano surgery and observation of the surgery results can be simultaneously achieved. This nano robot can be easily integrated with extra modules that have the potential applications of characterizing other properties of samples such as local conductance and capacitance.
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