Phenylacetylglutamine as a risk factor and prognostic indicator of heart failure.
Phenylacetylglutamine as a risk factor and prognostic indicator of heart failure.
复制标题
作者：
探讨血清苯乙酰谷氨酰胺（PAGln）与慢性心力衰竭（HF）的关系。从瑞金医院心血管内科连续入组956例受试者。所有参与者均获得基线数据，并对471名稳定型慢性心衰患者进行了随访。采用液相色谱-串联质谱法分析血清PAGln。通过简单相关分析评估PAGln与肾脏基本指标的相关性。Logistic回归分析PAGln与HF风险的相关性。Kaplan-Meier曲线确定无事件生存率，log - rank检验评估生存率差异。采用Cox比例风险分析评估PAGln在心衰患者中的预后价值。慢性HF患者血清PAGln水平升高（3.322±8.220 μM vs. 1.249±1.168 μM, P < 0.001），经完全校正后与HF相关[优势比（OR）， 1.507；95%置信区间（CI）： 1.213-1.873；p < 0.001]。PAGln水平与肾脏基本指标水平相关。高PAGln水平表明HF患者肾功能障碍风险高（OR: 1.853; 95% CI: 1.344-2.556; P < 0.001），而高PAGln水平与慢性HF患者心血管死亡风险高相关（HR: 2.049; 95% CI: 1.042-4.029; P = 0.038）。PAGln水平升高是心衰的独立危险因素，与心血管死亡风险升高相关。高水平的PAGln可能提示心衰患者肾功能不全。PAGln可以作为心衰的一个有价值的指标。
To explore the associations between serum phenylacetylglutamine (PAGln) and chronic heart failure (HF). Totally 956 subjects were enrolled consecutively from the Department of Cardiovascular Medicine, Ruijin Hospital. Baseline data were obtained from all participants, and 471 stable chronic HF subjects were followed up. Serum PAGln was analysed by liquid chromatography–tandem mass spectrometry. The association between PAGln and basic renal indicators was assessed by simple correlation analysis. Logistic regression analysis was conducted to measure the association between PAGln and HF risk. Event‐free survival was determined by Kaplan–Meier curves, and differences in survival were assessed using log‐rank tests. Cox proportional hazards analysis was used to assess the prognostic value of PAGln in HF. Serum PAGln levels were increased in patients with chronic HF (3.322 ± 8.220 μM vs. 1.249 ± 1.168 μM, P < 0.001) and were associated with HF after full adjustment [odds ratio (OR), 1.507; 95% confidence interval (CI): 1.213–1.873; P < 0.001]. PAGln levels were correlated with the levels of basic renal indicators. High PAGln levels indicated a high risk of renal dysfunction in HF (OR: 1.853; 95% CI: 1.344–2.556; P < 0.001), and elevated PAGln levels were associated with a high risk of cardiovascular death in patients with chronic HF (HR: 2.049; 95% CI: 1.042–4.029; P = 0.038). Elevated PAGln levels are an independent risk factor for HF and are associated with a higher risk of cardiovascular death. High PAGln levels could indicate renal dysfunction in HF patients. PAGln can be a valuable indicator of HF.
登录
查看更多内容
影响因子：
3.9
作者：
Andrade F;Cano A;Unceta Suarez M;Arza A;Vinuesa A;Ceberio L;López-Oslé N;de Frutos G;López-Oceja R;Aznal E;González-Lamuño D;de Las Heras J
通讯作者：
de Las Heras J
影响因子：
49.6
作者：
Bui, Anh L.;Horwich, Tamara B.;Fonarow, Gregg C.
通讯作者：
Fonarow, Gregg C.
影响因子：
3.7
作者：
Barrios C;Beaumont M;Pallister T;Villar J;Goodrich JK;Clark A;Pascual J;Ley RE;Spector TD;Bell JT;Menni C
通讯作者：
Menni C
影响因子：
3.5
作者：
Sandek, Anja;Bjarnason, Ingvar;Rauchhaus, Mathias
通讯作者：
Rauchhaus, Mathias
影响因子：
13.6
作者：
Poesen, Ruben;Claes, Kathleen;Meijers, Bjorn
通讯作者：
Meijers, Bjorn