Structure-function relationships in the feto-placental circulation from in silico interpretation of micro-CT vascular structures.
Structure-function relationships in the feto-placental circulation from in silico interpretation of micro-CT vascular structures.
复制标题
从micro-CT血管结构的计算机图像解释胎儿-胎盘循环的结构-功能关系。
DOI：
10.1016/j.jtbi.2021.110630
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发表时间：
2021-05-21
影响因子：
2
通讯作者：
Clark AR
中科院分区：
文献类型：
--
作者：
Byrne M;Aughwane R;James JL;Hutchinson JC;Arthurs OJ;Sebire NJ;Ourselin S;David AL;Melbourne A;Clark AR
功能良好的胎盘对于胎儿的健康发育至关重要，因为胎盘使胎儿血液与营养丰富的母体血液紧密接触，从而实现母亲和胎儿之间营养和废物的交换。胎儿胎盘循环形成复杂的分支结构，为胎儿毛细血管提供血液，胎儿毛细血管必须接收足够的血流以确保有效交换，但压力要足够低，以防止胎盘循环结构受损。已知胎儿胎盘循环的分支结构会在胎儿生长受限等并发症中发生改变，并且血管功能障碍区域（例如血管不足或血栓形成）的存在被认为会增加胎盘病理的风险。在这里，我们提出了一种方法，将微计算机断层扫描和基于计算模型的分析相结合，对正常足月妊娠的离体胎盘中胎儿胎盘循环的分支结构进行分析。我们分析血管结构如何与这一妊娠关键器官的功能相关；证明胎盘血管结构与功能关系具有“弹性”。我们发现，具有可变绒毛膜血管结构的胎盘，无论脐动脉之间有或没有Hyrtl吻合，以及具有多个血管化组织不良的区域的胎盘都能够以正常的血管阻力发挥作用。我们的模型还预测，通过逐步在胎盘血管结构中引入局部异质性，会诱导胎儿胎盘血管阻力的大幅增加。这表明胎盘结构的局部异质性可能提供胎盘功能障碍风险增加的指标。
A well-functioning placenta is critical for healthy fetal development, as the placenta brings fetal blood in close contact with nutrient rich maternal blood, enabling exchange of nutrients and waste between mother and fetus. The feto-placental circulation forms a complex branching structure, providing blood to fetal capillaries, which must receive sufficient blood flow to ensure effective exchange, but at a low enough pressure to prevent damage to placental circulatory structures. The branching structure of the feto-placental circulation is known to be altered in complications such as fetal growth restriction, and the presence of regions of vascular dysfunction (such as hypovascularity or thrombosis) are proposed to elevate risk of placental pathology. Here we present a methodology to combine micro-computed tomography and computational model-based analysis of the branching structure of the feto-placental circulation in ex vivo placentae from normal term pregnancies. We analyse how vascular structure relates to function in this key organ of pregnancy; demonstrating that there is a ‘resilience’ to placental vascular structure–function relationships. We find that placentae with variable chorionic vascular structures, both with and without a Hyrtl’s anastomosis between the umbilical arteries, and those with multiple regions of poorly vascularised tissue are able to function with a normal vascular resistance. Our models also predict that by progressively introducing local heterogeneity in placental vascular structure, large increases in feto-placental vascular resistances are induced. This suggests that localised heterogeneities in placental structure could potentially provide an indicator of increased risk of placental dysfunction.
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影响因子：
3.7
作者：
Pearce P;Brownbill P;Janáček J;Jirkovská M;Kubínová L;Chernyavsky IL;Jensen OE
通讯作者：
Jensen OE
影响因子：
3.8
作者：
Langheinrich, A. C.;Vorman, S.;Zygmunt, M.
通讯作者：
Zygmunt, M.
影响因子：
3.8
作者：
Mayhew, TM;Ohadike, C;Ong, SS
通讯作者：
Ong, SS
影响因子：
3
作者：
Aughwane, Rosalind;Ingram, Emma;Melbourne, Andrew
通讯作者：
Melbourne, Andrew
DOI：
10.1152/ajpheart.00510.2010
发表时间：
2011-02-01
影响因子：
4.8
作者：
Rennie, Monique Y.;Detmar, Jacqui;Sled, John G.
通讯作者：
Sled, John G.