A new FRAX model for Brazil.
A new FRAX model for Brazil.
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DOI：
10.1007/s11657-023-01354-3
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发表时间：
2023-11-28
影响因子：
3
通讯作者：
Kanis, J. A.
中科院分区：
文献类型：
--
作者：
Albergaria, B. H.;Zerbini, C. A. F.;Lazaretti-Castro, M.;Eis, S. R.;Vilaca, T.;Johansson, H.;Harvey, N. C.;Liu, E.;Vandenput, L.;Lorentzon, M.;Schini, M.;McCloskey, E.;Kanis, J. A.
将巴西原始FRAX模型得出的骨折概率与基于最近对髋部骨折发生率的地区估计的更新模型得出的骨折概率进行了比较。在更新的FRAX模型中，骨折概率一直较低。尽管模型之间的差异很大，但骨折概率的排序差异很小。最近的流行病学数据表明，巴西髋部骨折的风险低于创建原始FRAX模型时使用的风险。本文描述了巴西髋部骨折的流行病学和一个更新的FRAX模型的合成，目的是将这个新模型与原来的模型进行比较。将三个地区三个城市的髋部骨折发生率结合起来，按每个地区的人口加权。对于其他主要骨折，巴西的发病率是使用瑞典的髋部与其他主要骨质疏松性骨折(肱骨、前臂或临床脊椎骨折)的比率来估计的。死亡估计来自联合国。与原始的FRAX模型相比，更新后的模型给出了所有年龄段的男性和女性10年内骨折的概率更低。尽管如此，原始模型和更新模型(r >； 0.99)之间的骨折概率有非常密切的相关性，因此修订后的模型对风险等级顺序几乎没有影响。原始FRAX模型和更新的FRAX模型之间的差异表明，随着骨折流行病学的重大变化，更新特定国家的FRAX模型的重要性。
Fracture probabilities derived from the original FRAX model for Brazil were compared to those from an updated model based on more recent regional estimates of the incidence of hip fracture. Fracture probabilities were consistently lower in the updated FRAX model. Despite large differences between models, differences in the rank order of fracture probabilities were minimal. Recent epidemiological data indicate that the risk of hip fracture in Brazil is lower than that used to create the original FRAX model. This paper describes the epidemiology of hip fracture in Brazil and the synthesis of an updated FRAX model with the aim of comparing this new model with the original model. Hip fracture rates from three cities in three regions were combined, weighted by the population of each region. For other major fractures, incidence rates for Brazil were estimated using Swedish ratios for hip to other major osteoporotic fracture (humerus, forearm or clinical vertebral fractures). Mortality estimates were taken from the UN. Compared to the original FRAX model, the updated model gave lower 10-year fracture probabilities in men and women at all ages. Notwithstanding, there was a very close correlation in fracture probabilities between the original and updated models (r > 0.99) so that the revisions had little impact on the rank order of risk. The disparities between the original and updated FRAX models indicate the importance of updating country-specific FRAX models with the advent of significant changes in fracture epidemiology.
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影响因子：
4
作者：
Kanis, J. A.;Johansson, H.;McCloskey, E. V.
通讯作者：
McCloskey, E. V.
影响因子：
4
作者：
Johnell, O.;Borgstrom, F.;Kanis, J.
通讯作者：
Kanis, J.
影响因子：
4.1
作者：
Dela, S. S.;Paruk, F.;Cassim, B.
通讯作者：
Cassim, B.
影响因子：
3
作者：
Albergaria, Ben-Hur;Zerbini, Cristiano A. F.;Lazaretti-Castro, Marise
通讯作者：
Lazaretti-Castro, Marise
影响因子：
4
作者：
Kanis, J. A.;Hans, D.;McCloskey, E. V.
通讯作者：
McCloskey, E. V.