Effects of acute cannabis inhalation on reaction time, decision-making, and memory using a tablet-based application.
Effects of acute cannabis inhalation on reaction time, decision-making, and memory using a tablet-based application.
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DOI：
10.1186/s42238-024-00215-1
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发表时间：
2024-02-03
影响因子：
3.7
通讯作者：
Kosnett, Michael J.
中科院分区：
文献类型：
--
作者：
Brooks-Russell, Ashley;Wrobel, Julia;Brown, Tim;Bidwell, L. Cinnamon;Wang, George Sam;Steinhart, Benjamin;Dooley, Gregory;Kosnett, Michael J.
关键词：
急性大麻使用已被证明会减缓反应时间，影响决策和短期记忆。这些影响可能在识别与近期使用相关的损害方面具有实用性。然而，这些影响尚未在具有日常使用模式的个体中进行广泛研究，这些个体可能已经获得了耐受性。本研究的目的是研究大麻耐受性对反应时间，决策（间隙接受）和短期记忆的急性效应的影响。参与者（25-45岁）在吸食大麻花之前和之后大约60分钟完成了基于平板电脑（iPad）的测试电池。在三组大麻使用者中比较了大麻使用前后的性能变化：（1）偶尔使用（n = 23）;（2）每日使用（n = 31）;或（3）当前未使用（n = 32）。偶尔和每日使用组的参与者通过吸烟或吸电子烟随意自我管理，自我提供具有高浓度总THC（15-30%）的大麻花。与未使用组相比，偶尔使用组从使用大麻之前到之后的反应时间（减慢）和短期记忆（复制较少的形状）减少。在差距接受任务，日常使用的参与者需要更多的时间来完成任务后，吸烟大麻相比，那些没有使用或偶尔使用;然而，准确性水平没有显着变化。研究结果与每日使用大麻对某些急性精神病影响的后天耐受性一致。从差距接受任务中发现，速度下降但准确性没有下降，这可能表明准确性优先于响应时间。认知和心理评估可能有助于确定与最近使用大麻有关的损害。在线版本包含补充材料，可通过10.1186/s42238-024-00215-1获得。
Acute cannabis use has been demonstrated to slow reaction time and affect decision-making and short-term memory. These effects may have utility in identifying impairment associated with recent use. However, these effects have not been widely investigated among individuals with a pattern of daily use, who may have acquired tolerance. The purpose of this study was to examine the impact of tolerance to cannabis on the acute effects as measured by reaction time, decision-making (gap acceptance), and short-term memory. Participants (ages 25–45) completed a tablet-based (iPad) test battery before and approximately 60 min after smoking cannabis flower. The change in performance from before to after cannabis use was compared across three groups of cannabis users: (1) occasional use (n = 23); (2) daily use (n = 31); or (3) no current use (n = 32). Participants in the occasional and daily use group self-administered ad libitum, by smoking or vaping, self-supplied cannabis flower with a high concentration of total THC (15–30%). The occasional use group exhibited decrements in reaction time (slowed) and short-term memory (replicated fewer shapes) from before to after cannabis use, as compared to the no-use group. In the gap acceptance task, daily use participants took more time to complete the task post-smoking cannabis as compared to those with no use or occasional use; however, the level of accuracy did not significantly change. The findings are consistent with acquired tolerance to certain acute psychomotor effects with daily cannabis use. The finding from the gap acceptance task which showed a decline in speed but not accuracy may indicate a prioritization of accuracy over response time. Cognitive and psychomotor assessments may have utility for identifying impairment associated with recent cannabis use. The online version contains supplementary material available at 10.1186/s42238-024-00215-1.
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DOI：
10.1007/bf00428918
发表时间：
1974-01-01
期刊：
PSYCHOPHARMACOLOGIA
影响因子：
--
作者：
COHEN, MJ;RICKLES, WH
通讯作者：
RICKLES, WH
DOI：
10.1016/j.aap.2021.106326
发表时间：
2021-09
期刊：
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影响因子：
--
作者：
Brooks-Russell A;Brown T;Friedman K;Wrobel J;Schwarz J;Dooley G;Ryall KA;Steinhart B;Amioka E;Milavetz G;Sam Wang G;Kosnett MJ
通讯作者：
Kosnett MJ
影响因子：
3.4
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通讯作者：
Stough, Con
影响因子：
5
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通讯作者：
Dey, Anind K.
影响因子：
168.9
作者：
Hall, Wayne;Stjepanovic, Daniel;Degenhardt, Louisa
通讯作者：
Degenhardt, Louisa