Urinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence.
Urinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence.
复制标题
DOI：
10.1093/jat/32.8.562
复制
发表时间：
2008-10
影响因子：
2.5
通讯作者：
Huestis MA
中科院分区：
文献类型：
--
作者：
Goodwin RS;Darwin WD;Chiang CN;Shih M;Li SH;Huestis MA
在一个封闭的研究单位，在长达30天的24小时监测戒断期间，60名大麻使用者尿液中11-不-9-羧基-Δ9-tetrahydrocannnabinol （THCCOOH）消除的时间过程。6158例个体尿液经免疫分析筛选，≥50 ng/mL为阳性。尿液标本经碱水解、液-液或固相萃取后，采用气相色谱/质谱法确认含有四氯乙酸。在60%的病例中，肌酐正常化浓度最大值出现在第一次尿样中；40%的患者在入院后2.9天出现高峰。根据肌酸酐校正后的THCCOOH初始浓度，将数据分为0 ~ 50ng /mg、51 ~ 150 ng/mg和> ~ 150ng /mg三组。两组患者第一次尿呈阴性和最后一次尿呈阳性的天数之间存在显著的统计学相关性；三组的平均天数分别为0.6天和4.3天、3.2天和9.7天、4.7天和15.4天。这些数据为解释尿大麻素测试结果提供了指导方针，并建议了区分新大麻使用和残留药物排泄的适当检测窗口。
The time course of 11-nor-9-carboxy-Δ9-tetrahydrocannnabinol (THCCOOH) elimination in urine was characterized in 60 cannabis users during 24 h monitored abstinence on a closed research unit for up to 30 days. 6158 individual urine specimens were screened by immunoassay with values ≥50 ng/mL classified as positive. Urine specimens were confirmed for THCCOOH by gas chromatography/mass spectrometry following base hydrolysis and liquid-liquid or solid phase extraction. In 60%, the maximum creatinine normalized concentration occurred in the first urine specimen; in 40%, peaks occurred as long as 2.9 days after admission. Data were divided into three groups, 0 – 50, 51 – 150, and >150 ng/mg, based on the creatinine corrected initial THCCOOH concentration. There were statistically significant correlations between groups and number of days until first negative and last positive urine specimens; mean number of days were 0.6 and 4.3, 3.2 and 9.7, and 4.7 and 15.4 days respectively, for the three groups. These data provide guidelines for interpreting urine cannabinoid test results and suggest appropriate detection windows for differentiating new cannabis use from residual drug excretion.
登录
查看更多内容
影响因子：
4.2
作者：
Vega, WA;Aguilar-Gaxiola, S;Wittchen, HU
通讯作者：
Wittchen, HU
影响因子：
6.7
作者：
ELLIS, GM;MANN, MA;TASHCHIAN, A
通讯作者：
TASHCHIAN, A
影响因子：
2.5
作者：
KELLY, P;JONES, RT
通讯作者：
JONES, RT
影响因子：
2.5
作者：
JOHANSSON, E;HALLDIN, MM
通讯作者：
HALLDIN, MM
影响因子：
2.5
作者：
Crockett, DK;Nelson, G;Urry, FM
通讯作者：
Urry, FM