Flexible scaling and persistence of social vocal communication.
Flexible scaling and persistence of social vocal communication.
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社会声音交流的灵活缩放和持久性。
DOI：
10.1038/s41586-021-03403-8
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发表时间：
2021-05
期刊：
影响因子：
64.8
通讯作者：
Stowers, Lisa
中科院分区：
文献类型：
--
作者：
Chen, Jingyi;Markowitz, Jeffrey E.;Lilascharoen, Varoth;Taylor, Sandra;Sheurpukdi, Pete;Keller, Jason A.;Jensen, Jennifer R.;Lim, Byung Kook;Datta, Sandeep Robert;Stowers, Lisa
天生的声音，如笑，尖叫，或哭传达一个人的感情给别人。在包括人类在内的许多物种中，调整发声的幅度和持续时间对于有效的社会沟通至关重要。在小鼠中，雌性气味触发雄性发出天生的求爱超声波发声（USV）。然而，小鼠是否灵活地调整其发声以及神经回路如何构造以产生灵活性仍然在很大程度上未知。在这里，我们确定了外侧视前区神经元表达雌激素受体1（LPOAEsr 1）的激活elavour的完整剧目的USV音节在自然求偶过程中发出。神经解剖学和功能数据揭示了一个两步，双突触，电路基序，其中主要的长距离抑制性LPOAEsr 1神经元解除局部导水管周围灰质（PAG）抑制的钳位，使兴奋性PAG USV门控神经元触发发声。我们发现，社会背景的形状范围广泛的USV振幅和回合持续时间。当PAG神经元被直接刺激时，这种变化是不存在的; PAG诱发的发声被时间锁定到神经活动和刻板的响亮。相比之下，增加LPOAEsr 1活性可缩放呼叫幅度并延迟抑制钳的恢复。因此，LPOA去抑制基序有助于灵活的响度，持续时间和持久性，这些都是有效的语音社交的关键方面。
Innate vocal sounds such as laughing, screaming, or crying convey one’s feelings to others. In many species, including humans, scaling the amplitude and duration of vocalizations is essential for effective social communication. In mice, female scent triggers males to emit innate courtship ultrasonic vocalizations (USVs). However, whether mice flexibly scale their vocalizations and how neural circuits are structured to generate flexibility remains largely unknown. Here we identify lateral preoptic area neurons expressing estrogen receptor 1 (LPOAEsr1) whose activation elicits the complete repertoire of USV syllables emitted during natural courtship. Neural anatomy and functional data reveal a two-step, di-synaptic, circuit motif where primary long range inhibitory LPOAEsr1 neurons relieve a clamp of local periaqueductal gray (PAG) inhibition, enabling excitatory PAG USV-gating neurons to trigger vocalizations. We find that social context shapes a wide range of USV amplitudes and bout durations. This variability is absent when PAG neurons are directly stimulated; PAG-evoked vocalizations are time-locked to neural activity and stereotypically loud. In contrast, increasing LPOAEsr1 activity scales call amplitude and delaying recovery of the inhibition clamp prolongs USV bouts. Thus, the LPOA disinhibition motif contributes to flexible loudness, bout-duration, and persistence, which are key aspects of effective vocal social communication.
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影响因子：
48
作者：
Kim CK;Yang SJ;Pichamoorthy N;Young NP;Kauvar I;Jennings JH;Lerner TN;Berndt A;Lee SY;Ramakrishnan C;Davidson TJ;Inoue M;Bito H;Deisseroth K
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内侧视前区调节成年雄性小鼠求偶超声波发声
影响因子：
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作者：
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通讯作者：
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