Prefrontal vulnerabilities and whole brain connectivity in aging and depression.
Prefrontal vulnerabilities and whole brain connectivity in aging and depression.
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DOI：
10.1016/j.neuropsychologia.2013.05.004
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发表时间：
2013-07
期刊：
影响因子：
2.6
通讯作者：
Kumar A
中科院分区：
文献类型：
--
作者：
Lamar M;Charlton RA;Ajilore O;Zhang A;Yang S;Barrick TR;Rhodes E;Kumar A
探索与年龄相关的神经退行性变的基础的研究表明，额叶边缘系统的改变在包括晚年抑郁症在内的疾病的存在下越来越脆弱。较少的工作评估了这种特定脆弱性对广泛的大脑回路的影响。79名老年人（健康对照组=45;晚年抑郁症=34）完成了非人类灵长类动物的翻译任务，依赖于涉及背外侧（自我排序指向任务）或眶额（对象交替任务）皮质的额叶边缘系统网络。参与者的子样本还完成了白色物质束定量（钩椎和扣带回束; n=58）和基于全脑束的空间统计（n=62）的扩散张量成像。尽管两组的任务与特定的白色物质束有关，但只有健康对照组表现出广泛的束完整性和认知之间的显著相关性。因此，增加对象交替任务错误与减少分数各向异性在钩在晚年抑郁症，然而，只有在健康对照组被纳入一个更大的网络的白色物质的脆弱性关联分数各向异性与对象交替任务错误使用全脑束为基础的空间统计。看来，在衰老过程中特定的额边缘系统脆弱性对整个大脑的影响可能会在疾病特异性神经病理学的存在下黯然失色，比如在晚年抑郁症中看到的。
Studies exploring the underpinnings of age-related neurodegeneration suggest fronto-limbic alterations that are increasingly vulnerable in the presence of disease including late life depression. Less work has assessed the impact of this specific vulnerability on widespread brain circuitry. Seventy-nine older adults (healthy controls=45; late life depression=34) completed translational tasks shown in non-human primates to rely on fronto-limbic networks involving dorsolateral (Self-Ordered Pointing Task) or orbitofrontal (Object Alternation Task) cortices. A sub-sample of participants also completed diffusion tensor imaging for white matter tract quantification (uncinate and cingulum bundle; n=58) and whole brain tract-based spatial statistics (n=62). Despite task associations to specific white matter tracts across both groups, only healthy controls demonstrated significant correlations between widespread tract integrity and cognition. Thus, increasing Object Alternation Task errors were associated with decreasing fractional anisotropy in the uncinate in late life depression; however, only in healthy controls was the uncinate incorporated into a larger network of white matter vulnerability associating fractional anisotropy with Object Alternation Task errors using whole brain tract-based spatial statistics. It appears that the whole brain impact of specific fronto-limbic vulnerabilities in aging may be eclipsed in the presence of disease-specific neuropathology like that seen in late life depression.
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影响因子：
7.2
作者：
Aizenstein, Howard J.;Butters, Meryl A.;Wu, Minjie;Mazurkewicz, Laura M.;Stenger, V. Andrew;Gianaros, Peter J.;Becker, James T.;Reynolds, Cbarles F., III;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
3.2
作者：
Corbetta, M;Kincade, JM;Shulman, GL
通讯作者：
Shulman, GL
影响因子：
6.6
作者：
Kertzman, Semion;Reznik, Ilya;Amital, Daniela
通讯作者：
Amital, Daniela
影响因子：
2.6
作者：
Lamar M;Charlton R;Zhang A;Kumar A
通讯作者：
Kumar A