The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer.
The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer.
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DOI：
10.1007/s10555-010-9233-4
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发表时间：
2010-09
影响因子：
9.2
通讯作者：
Kong, Dejuan
中科院分区：
文献类型：
--
作者：
Sarkar, Fazlul H.;Li, Yiwei;Wang, Zhiwei;Kong, Dejuan
多种细胞信号通路参与了癌细胞的侵袭和转移过程。在众多信号通路中，Wnt和Hedgehog(HH)信号通路在胚胎发育、肿瘤干细胞(CSCs)生物学和上皮向间充质转化(EMT)的获得中起关键作用，因此本文将继续关注Wnt和HH信号通路。由于CSCs和EMT也被认为与癌细胞的侵袭和转移有关，Wnt和Hedgehog信号通路也与肿瘤的侵袭和转移密切相关。新出现的证据表明，通常被称为营养食品的化学预防药物在癌症中具有有益的作用。其中，大豆异黄酮类、姜黄素、绿茶多酚、3，3‘-二吲哚甲烷、白藜芦醇、番茄红素、维生素D等已被发现可预防、逆转或延缓致癌过程。有趣的是，这些药物还被证明可以预防或延缓癌症的进展，这可能部分是由于它们通过减弱Wnt和Hedgehog信号通路来攻击CSCs或EMT类型细胞的能力。在本文中，我们总结了Wnt和Hedgehog信号通路的作用，以及它们被化学预防药物(营养制剂)靶向失活以防止肿瘤进展和/或治疗人类恶性肿瘤的知识现状。
Multiple cellular signaling pathways have been involved in the processes of cancer cell invasion and metastasis. Among many signaling pathways, Wnt and Hedgehog (Hh) signaling pathways are critically involved in embryonic development, in the biology of cancer stem cells (CSCs) and in the acquisition of epithelial to mesenchymal transition (EMT), and thus this article will remain focused on Wnt and Hh signaling. Since CSCs and EMT are also known to be responsible for cancer cell invasion and metastasis, the Wnt and Hedgehog signaling pathways are also intimately associated with cancer invasion and metastasis. Emerging evidence suggests the beneficial role of chemopreventive agents commonly known as nutraceutical in cancer. Among many such agents, soy isoflavones, curcumin, green tea polyphenols, 3,3′-diindolylmethane, resveratrol, lycopene, vitamin D, etc. have been found to prevent, reverse, or delay the carcinogenic process. Interestingly, these agents have also shown to prevent or delay the progression of cancer, which could in part be due to their ability to attack CSCs or EMT-type cells by attenuating the Wnt and Hedgehog signaling pathways. In this review, we summarize the current state of our knowledge on the role of Wnt and Hedgehog signaling pathways, and their targeted inactivation by chemopreventive agents (nutraceuticals) for the prevention of tumor progression and/or treatment of human malignancies.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1152/ajpgi.00292.2009
发表时间：
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