Application of Nucleic Acid Frameworks in the Construction of Nanostructures and Cascade Biocatalysts: Recent Progress and Perspective.
Application of Nucleic Acid Frameworks in the Construction of Nanostructures and Cascade Biocatalysts: Recent Progress and Perspective.
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DOI：
10.3389/fbioe.2021.792489
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发表时间：
2021
影响因子：
5.7
通讯作者：
Chen T
中科院分区：
文献类型：
--
作者：
Zhu G;Song P;Wu J;Luo M;Chen Z;Chen T
核酸是所有生物遗传信息的存储和检索的基础，也为我们提供了制造人工纳米结构和构建多酶系统的支架的优良材料，由于其高度多样化和可控的结构，它们的序列决定了它们在催化各种级联反应方面的卓越性能。将非自然片段引入核酸，极大地增加了核酸序列、结构和性质的多样性，这无疑扩大了制造纳米材料和多酶系统支架的工具箱。本文首先介绍了核酸及其非天然衍生物的分子结构和性质。综述了具有代表性的核酸人工纳米材料及其性质、功能和应用。下面就以核酸结构为支架构建多酶体系的研究进展进行综述。最后，我们讨论了核酸框架在纳米材料和多酶分子机器构建中的应用方向，并强调了非天然核酸在该领域的潜在贡献。
Nucleic acids underlie the storage and retrieval of genetic information literally in all living organisms, and also provide us excellent materials for making artificial nanostructures and scaffolds for constructing multi-enzyme systems with outstanding performance in catalyzing various cascade reactions, due to their highly diverse and yet controllable structures, which are well determined by their sequences. The introduction of unnatural moieties into nucleic acids dramatically increased the diversity of sequences, structures, and properties of the nucleic acids, which undoubtedly expanded the toolbox for making nanomaterials and scaffolds of multi-enzyme systems. In this article, we first introduce the molecular structures and properties of nucleic acids and their unnatural derivatives. Then we summarized representative artificial nanomaterials made of nucleic acids, as well as their properties, functions, and application. We next review recent progress on constructing multi-enzyme systems with nucleic acid structures as scaffolds for cascade biocatalyst. Finally, we discuss the future direction of applying nucleic acid frameworks in the construction of nanomaterials and multi-enzyme molecular machines, with the potential contribution that unnatural nucleic acids may make to this field highlighted.
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