A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis.
A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis.
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一种基于生物材料的疗法，使用透明质酸钠/生物玻璃复合水凝胶来治疗口腔粘膜下纤维化。
DOI：
10.1016/j.actbio.2022.12.006
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发表时间：
2022-12
期刊：
影响因子：
--
通讯作者：
Kai Jiao
中科院分区：
文献类型：
--
作者：
Zhenxing Guo;Zhaowenbin Zhang;Jianfei Yan;Haoqing Xu;Shuyan Wang;Tao Ye;Xiaoxiao Han;Wanrong Wang;Yue Wang;Jialu Gao;Lina Niu;Jiang Chang;Kai Jiao
口腔粘膜下纤维化（OSF）是一种慢性、炎症性和潜在恶性的口腔疾病。其病理生理极其复杂，包括胶原过度沉积、大量炎症浸润、毛细血管萎缩等。但现有的临床治疗方法并未充分考虑OSF的全部病理生理过程，普遍疗效较低且副作用较多。在本研究中，我们开发了一种可注射的透明质酸钠/45S5生物玻璃复合水凝胶（BG/HA），可显着缓解OSF大鼠的粘膜苍白和张口受限，且没有任何明显的副作用。 BG/HA治疗OSF的核心机制是释放具有生物活性的硅酸盐离子，抑制胶原沉积和炎症，促进血管生成和上皮再生。最有趣的是，硅酸盐离子可以通过下调α-平滑肌肌动蛋白（α-SMA）和CD68以及上调CD31表达，以及调节促纤维化因子[转化生长因子-β1（TGF-β1）、白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）和金属蛋白酶-1组织抑制剂的表达来全面调节OSF的生理环境。 (TIMP-1)]和巨噬细胞中的抗纤维化因子[白细胞介素-1β (IL-1β)]。综上所述，我们的研究表明BG/HA在OSF的临床治疗中具有巨大的潜力，为后续开发新型抗纤维化临床制剂提供了重要的理论基础。 意义声明：口腔粘膜下纤维化（OSF）是一种慢性、炎症性和潜在恶性的粘膜疾病，对患者的生活质量产生重大影响。然而，现有的临床治疗方法疗效有限且副作用较多。迫切需要开发治疗OSF的特效药物。在本研究中，生物玻璃（BG）与透明质酸钠溶液（HA）复合用于治疗槟榔碱诱导的大鼠模型中的OSF。 BG/HA可以显着抑制胶原沉积、调节炎症反应、促进血管生成和修复受损的粘膜上皮细胞，从而减轻体内纤维化的发展。
Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant oral disorder. Its pathophysiology is extremely complex, including excessive collagen deposition, massive inflammatory infiltration, and capillary atrophy. However, the existing clinical treatment methods do not fully take into account all the pathophysiological processes of OSF, so they are generally low effective and have many side effects. In the present study, we developed an injectable sodium hyaluronate/45S5 bioglass composite hydrogel (BG/HA), which significantly relieved mucosal pallor and restricted mouth opening in OSF rats without any obvious side effects. The core mechanism of BG/HA in the treatment of OSF is the release of biologically active silicate ions, which inhibit collagen deposition and inflammation, and promote angiogenesis and epithelial regeneration. Most interestingly, silicate ions can overall regulate the physiological environment of OSF by down-regulating α-smooth muscle actin (α-SMA) and CD68 and up-regulating CD31 expression, as well as regulating the expression of pro-fibrotic factors [transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and tissue inhibitors of metalloproteinase-1 (TIMP-1)] and anti-fibrotic factors [interleukin-1β (IL-1β)] in macrophage. In conclusion, our study shows that BG/HA has great potential in the clinical treatment of OSF, which provides an important theoretical basis for the subsequent development of new anti-fibrotic clinical preparations.Statement of significance: Oral submucous fibrosis (OSF) is a chronic, inflammatory and potentially malignant mucosal disease with significant impact on the quality of patients’ life. However, the existing clinical treatments have limited efficacy and many side effects. There is an urgent need for development of specific drugs for OSF treatment. In the present study, bioglass (BG) composited with sodium hyaluronate solution (HA) was used to treat OSF in an arecoline-induced rat model. BG/HA can significantly inhibit collagen deposition, regulate inflammatory response, promote angiogenesis and repair damaged mucosal epithelial cells, and thereby mitigate the development of fibrosisin vivo.
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影响因子：
14
作者：
Sun Jin Long;Jiao Kai;Niu Li Na;Jiao Yang;Song Qun;Shen Li Juan;Tay Franklin R;Chen Ji Hua
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影响因子：
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作者：
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影响因子：
9.7
作者：
Huang, Yan;Wu, Chengtie;Dai, Kerong
通讯作者：
Dai, Kerong
DOI：
10.1007/s10856-012-4844-7
发表时间：
2013-01
期刊：
Journal of Materials Science: Materials in Medicine
影响因子：
--
作者：
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A. Ma;Nian Gong;J. Lu;Jin-lu Huang;B. Hao;Yang Guo;Jipin Zhong;Yuhong Xu;Jiang Chang;Yongxiang Wang
影响因子：
5.2
作者：
Hester, K. L. M.;Powell, T.;Jarad, N. A.
通讯作者：
Jarad, N. A.