Association of Long-Term Diet Quality with Hippocampal Volume: Longitudinal Cohort Study.
Association of Long-Term Diet Quality with Hippocampal Volume: Longitudinal Cohort Study.
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DOI：
10.1016/j.amjmed.2018.07.001
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Kivimaki M
中科院分区：
文献类型：
--
作者：
Akbaraly T;Sexton C;Zsoldos E;Mahmood A;Filippini N;Kerleau C;Verdier JM;Virtanen M;Gabelle A;Ebmeier KP;Kivimaki M
饮食质量与大脑老化结果有关。然而，很少有研究探索人类大脑结构可能受到长期饮食质量的影响。我们研究了成年期（11年暴露期）替代健康饮食指数2010（AHEI-2010）评分的累积平均值是否与海马体积相关。分析基于Whitehall II成像子研究的459名参与者的数据（2002-2004年平均年龄[标准差]（SD）= 59.6 [5.3]岁，19.2%为女性）。随访结束时（2015-2016年）进行多模态磁共振成像检查。使用高分辨率三维T1加权序列获得结构图像，并使用脑功能磁共振成像软件库（FSL）工具进行处理。应用基于模型的自动分割和配准工具提取海马体积。较高的AHEI-2010累积平均评分（反映长期健康饮食质量）与较大的总海马体积相关。AHEI-2010评分每增加1 SD（SD = 8.7分），观察到海马总体积增加92.5 mm 3（标准误= 42.0 mm 3）。这种关联独立于社会人口统计学因素、吸烟习惯、体力活动、心脏代谢健康因素、认知障碍和抑郁症状，并且在左侧海马体中比右侧海马体更明显。在AHEI-2010的组成部分中，没有或少量饮酒与较大的海马体积独立相关。较高的长期AHEI-2010评分与较大的海马体积相关。考虑到海马结构在几种神经精神疾病中的重要性，我们的研究结果重申了在多干预计划中考虑坚持健康饮食建议以促进健康大脑衰老的必要性。
Diet quality is associated with brain aging outcomes. However, few studies have explored in humans the brain structures potentially affected by long-term diet quality. We examined whether cumulative average of the Alternative Healthy Eating Index 2010 (AHEI-2010) score during adult life (an 11-year exposure period) is associated with hippocampal volume. Analyses were based on data from 459 participants of the Whitehall II imaging sub-study (mean age [standard deviation] (SD) = 59.6 [5.3] years in 2002-2004, 19.2% women). Multimodal magnetic resonance imaging examination was performed at the end of follow-up (2015-2016). Structural images were acquired using a high-resolution 3-dimensional T1-weighted sequence and processed with Functional Magnetic Resonance Imaging of the Brain Software Library (FSL) tools. An automated model-based segmentation and registration tool was applied to extract hippocampal volumes. Higher AHEI-2010 cumulative average score (reflecting long-term healthy diet quality) was associated with a larger total hippocampal volume. For each 1 SD (SD = 8.7 points) increment in AHEI-2010 score, an increase of 92.5 mm3 (standard error = 42.0 mm3) in total hippocampal volume was observed. This association was independent of sociodemographic factors, smoking habits, physical activity, cardiometabolic health factors, cognitive impairment, and depressive symptoms, and was more pronounced in the left hippocampus than in the right hippocampus. Of the AHEI-2010 components, no or light alcohol consumption was independently associated with larger hippocampal volume. Higher long-term AHEI-2010 scores were associated with larger hippocampal volume. Accounting for the importance of hippocampal structures in several neuropsychiatric diseases, our findings reaffirm the need to consider adherence to healthy dietary recommendation in multi-interventional programs to promote healthy brain aging.
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影响因子：
--
作者：
Agartz, I;Momenan, R;Hommer, DW
通讯作者：
Hommer, DW
影响因子：
5.7
作者：
Patenaude, Brian;Smith, Stephen M.;Kennedy, David N.;Jenkinson, Mark
通讯作者：
Jenkinson, Mark
DOI：
10.3233/jad-2010-091414
发表时间：
2010
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Kanoski SE;Zhang Y;Zheng W;Davidson TL
通讯作者：
Davidson TL
影响因子：
--
作者：
Gardener, Hannah;Scarmeas, Nikolaos;Wright, Clinton B.
通讯作者：
Wright, Clinton B.
影响因子：
9.9
作者：
Gu, Yian;Brickman, Adam M.;Scarmeas, Nikolaos
通讯作者：
Scarmeas, Nikolaos