Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children.
Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children.
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DOI：
10.1038/s41597-020-00668-y
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发表时间：
2020-10-15
期刊：
影响因子：
9.8
通讯作者：
Moss PAH
中科院分区：
文献类型：
--
作者：
Glynn JR;Moss PAH
新冠肺炎大流行点燃了人们对感染特定年龄表现的兴趣，但令人惊讶的是，人们对极端年龄之间传染病的相对严重程度知之甚少。在系统分析中，我们确定了142个数据集，其中包含32种不同传染病、19种病毒和13种细菌的按年龄划分的疾病严重程度信息。对于几乎所有的感染，学龄儿童的疾病最轻，严重程度早在老年之前就开始上升。事实上，对于许多感染来说，即使是年轻人也比儿童患有更严重的疾病，而登革热是学龄儿童中唯一最严重的感染。结合儿童和年轻人的疫苗反应数据，研究结果表明，免疫功能在5-14岁左右达到峰值。相对免疫衰老可能比假设的要早得多，在老年人群中加速。这对于理解对感染的复原力、最佳疫苗计划和整个生命周期的适当卫生保护政策具有重大意义。
The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of infectious disease between the extremes of age. In a systematic analysis we identified 142 datasets with information on severity of disease by age for 32 different infectious diseases, 19 viral and 13 bacterial. For almost all infections, school-age children have the least severe disease, and severity starts to rise long before old age. Indeed, for many infections even young adults have more severe disease than children, and dengue was the only infection that was most severe in school-age children. Together with data on vaccine response in children and young adults, the findings suggest peak immune function is reached around 5–14 years of age. Relative immune senescence may begin much earlier than assumed, before accelerating in older age groups. This has major implications for understanding resilience to infection, optimal vaccine scheduling, and appropriate health protection policies across the life course.
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