Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures.

Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures.
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锻造环:从真菌脓毒症在形态、分隔和毒力方面的不同作用,到有助于其组装成更高阶结构的因素。

DOI:
10.1099/mic.0.000359
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发表时间:
2016
期刊:
Microbiology (Reading, England)
影响因子:
--
通讯作者:
Steinbach,WilliamJ
Steinbach,WilliamJ
中科院分区:
--
文献类型:
--
作者:
Vargas-Muñiz,JoseM;Juvvadi,PraveenR;Steinbach,WilliamJ

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Septins是一个保守的GTP结合蛋白家族,分布于除植物外的真核生物的不同谱系中。隔膜蛋白在真菌细胞中执行无数功能,范围从控制形态发生事件到促进宿主组织入侵和毒力。septins的一个关键属性是它们组装成异源寡聚复合物的能力,所述异源寡聚复合物组织成更高级的结构。除了在模型芽殖酵母(Saccharomycescerevisiae)中确立的septins作用外,它们在其他真菌中的重要性最近出现。虽然septins在这些真菌中的新作用正在被发现,但septins如何组装成复合物及其调节的机制才刚刚开始被理解。本文综述了septins在不同真菌中的作用,并重点介绍了不同真菌septins复合物在体外和体内的组织结构。此外,我们还讨论了磷酸化/去磷酸化如何作为septin复合物组装和调节的重要机制。
Septins are a conserved family of GTP-binding proteins that are distributed across different lineages of the eukaryotes, with the exception of plants. Septins perform a myriad of functions in fungal cells, ranging from controlling morphogenetic events to contributing to host tissue invasion and virulence. One key attribute of the septins is their ability to assemble into heterooligomeric complexes that organizse into higher order structures. In addition to the established role of septins in the model budding yeast,Saccharomyces cerevisiae, their importance in other fungi recently emerges. While newer roles for septins are being uncovered in these fungi, the mechanism of how septins assemble into a complex and their regulation is only beginning to be comprehended. In this review, we summarize recent findings on the role of septins in different fungi and focus on how the septin complexes of different fungi are organizedin vitroandin vivo. Furthermore, we discuss on how phosphorylation/dephosphorylation can serve as an important mechanism of septin complex assembly and regulation.
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