Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice.
Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice.
复制标题
DOI：
10.1038/s41467-021-24074-z
复制
发表时间：
2021-06-22
影响因子：
16.6
通讯作者：
Devkota S
中科院分区：
文献类型：
--
作者：
Martin A;Ecklu-Mensah G;Ha CWY;Hendrick G;Layman DK;Gilbert J;Devkota S
长期限制蛋白质摄入可造成必需氨基酸缺乏，并通过肝脏FGF21途径诱导代谢适应，从而在营养失衡的长期状态下维持宿主的健康。同样，当添加或停止饮食营养时，肠道微生物群经历新陈代谢适应。在这里，我们证实了先前的报道，即限制饮食蛋白质会触发肝脏FGF21适应代谢途径，并进一步证明这种反应是由肠道微生物群介导的，可以通过饮食补充改变肠道微生物群的纤维来调节。在没有肠道微生物的情况下，我们发现FGF21对蛋白质限制的影响是不敏感的。这些数据表明，宿主对慢性饮食蛋白质限制的内在适应途径，如肝脏FGF21途径，实际上可能首先对肠道微生物组的适应性代谢变化做出反应。限制饮食蛋白诱导由内分泌分子FGF21介导的肝脏应激反应，从而触发宿主适应途径。在这里，作者证明了肠道微生物群是触发FGF21反应所必需的，并且可以通过补充膳食纤维来操纵。
Chronic dietary protein-restriction can create essential amino acid deficiencies and induce metabolic adaptation through the hepatic FGF21 pathway which serves to maintain host fitness during prolonged states of nutritional imbalance. Similarly, the gut microbiome undergoes metabolic adaptations when dietary nutrients are added or withdrawn. Here we confirm previous reports that dietary protein-restriction triggers the hepatic FGF21 adaptive metabolic pathway and further demonstrate that this response is mediated by the gut microbiome and can be tuned through dietary supplementation of fibers that alter the gut microbiome. In the absence of a gut microbiome, we discover that FGF21 is de-sensitized to the effect of protein-restriction. These data suggest that host-intrinsic adaptive pathways to chronic dietary protein-restriction, such as the hepatic FGF21 pathway, may in-fact be responding first to adaptive metabolic changes in the gut microbiome. Dietary protein restriction induces a hepatic stress response mediated by the endocrine molecule FGF21, which triggers host adaptive pathways. Here the authors demonstrate that the gut microbiome is required to trigger the FGF21 response and can be manipulated through dietary fiber supplementation.
登录
查看更多内容
影响因子：
12.2
作者：
Holscher HD
通讯作者：
Holscher HD
DOI：
10.1038/s41366-018-0080-7
发表时间：
2018-06
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Andersen B;Straarup EM;Heppner KM;Takahashi DL;Raffaele V;Dissen GA;Lewandowski K;Bödvarsdottir TB;Raun K;Grove KL;Kievit P
通讯作者：
Kievit P
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
2.7
作者：
Kismul H;Van den Broeck J;Lunde TM
通讯作者：
Lunde TM
影响因子：
8.1
作者：
Pissios, Pavlos;Hong, Shangyu;Maratos-Flier, Eleftheria
通讯作者：
Maratos-Flier, Eleftheria