Paclitaxel inhibits post-traumatic recurrent laryngeal nerve regeneration into the posterior cricoarytenoid muscle in a canine model.
Paclitaxel inhibits post-traumatic recurrent laryngeal nerve regeneration into the posterior cricoarytenoid muscle in a canine model.
复制标题
在犬模型中，紫杉醇抑制创伤后喉返神经再生为后环杓肌。
DOI：
10.1002/lary.26058
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Paniello,RandalC
中科院分区：
文献类型：
--
作者：
Park,AndreaM;Bhatt,NeelK;Paniello,RandalC
Objectives/HypothesisTo investigate paclitaxel，一种有效的微管抑制剂，与长春新碱相比具有更有利的治疗指数，在犬喉模型中预防喉返神经进入环杓后肌的创伤后神经再生的有效性。Study DesignExperimental animal study. Methods将49只犬半喉标本分为5个实验组。在全身麻醉下，气管切开术，喉返神经（RLN）切断和修复，喉内收压（RLN）进行了测量前RLN损伤。在0或3个月时，神经毒素注射的环杓后肌（PCA）入路为经口或开放性经颈入路。在6个月，伤后LAPs进行测量，并在6个月的动物被处死，以允许喉收获和analysis. ResultsPaclitazone表现出增加的平均喉内收压力（70.6%）相比，生理盐水对照组（55.5%）。紫杉醇的作用与长春新碱在0个月时和延迟注射在3个月时观察到的作用相同。经口或开放式注射groups.ConclusionsPCA肌肉注射紫杉醇导致喉内收的改善强度之间没有差异。在神经损伤后0个月和3个月，这种作用与长春新碱相似。紫杉醇单次肌肉注射耐受性良好。需要进行额外的人体研究来确定这种干预的临床受益程度。证据水平NALryngoscope，127：651-655，2017
Objectives/HypothesisTo investigate the efficacy of paclitaxel, a potent microtubule inhibitor with a more favorable therapeutic index as compared with vincristine, in preventing post‐traumatic nerve regeneration of the recurrent laryngeal nerve into the posterior cricoarytenoid muscle in a canine laryngeal model.Study DesignExperimental animal study.MethodsForty‐nine canine hemilaryngeal specimens were divided into five experimental groups. Under general anesthesia, a tracheostomy, recurrent laryngeal nerve (RLN) transection and repair, and laryngeal adductory pressures (LAP) were measured pre–RLN injury. The approach to the posterior cricoarytenoid (PCA) muscle for neurotoxin injection was transoral or open transcervical, at 0 or 3 months. At 6 months, postinjury LAPs were measured and the animals were sacrificed at 6 months to allow for laryngeal harvesting and analysis.ResultsPaclitaxel demonstrated increased mean laryngeal adductory pressures (70.6%) as compared with saline control (55.5%). The effect of paclitaxel was the same as observed with vincristine at 0 months and with a delayed injection at 3 months. There was no difference between transoral or open injection groups.ConclusionsPCA muscle injection with paclitaxel resulted in improved strength of laryngeal adduction. This effect was similar to that of vincristine at both 0 and 3 months following nerve injury. A single intramuscular injection of paclitaxel was well tolerated. Additional human studies are needed to determine the degree of clinical benefit of this intervention.Level of EvidenceNALaryngoscope, 127:651–655, 2017
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DOI：
10.1111/j.1749-6632.1982.tb22124.x
发表时间：
1982-01-01
影响因子：
5.2
作者：
KUSHNER, I
通讯作者：
KUSHNER, I
重组人肿瘤坏死因子对内源激素作用的调节。
DOI：
10.1073/pnas.84.23.8619
发表时间：
1987
影响因子：
11.1
作者：
Warren,RS;Donner,DB;StarnesJr,HF;Brennan,MF
通讯作者：
Brennan,MF
通过在正常和受伤受试者中输注非同位素甘油来测量甘油周转率。
DOI：
10.1152/ajpendo.1984.247.3.e405
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
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作者：
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通讯作者：
Kinney,JM
影响因子：
15.9
作者：
SIMMONS, PS;MILES, JM;HAYMOND, MW
通讯作者：
HAYMOND, MW
肿瘤坏死因子给药对人体的急性代谢影响。
DOI：
10.1001/archsurg.1987.01400240042007
发表时间：
1987
期刊：
Archives of surgery (Chicago, Ill. : 1960)
影响因子：
--
作者：
Warren,RS;StarnesJr,HF;Gabrilove,JL;Oettgen,HF;Brennan,MF
通讯作者：
Brennan,MF