Assessing the barriers to image-guided drug delivery.
Assessing the barriers to image-guided drug delivery.
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DOI：
10.1002/wnan.1247
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发表时间：
2014-01
影响因子：
8.6
通讯作者：
Farahani, Keyvan
中科院分区：
文献类型：
--
作者：
Lanza, Gregory M.;Moonen, Chrit;Baker, James R., Jr.;Chang, Esther;Cheng, Zheng;Grodzinski, Piotr;Ferrara, Katherine;Hynynen, Kullervo;Kelloff, Gary;Lee, Yong-Eun Koo;Patri, Anil K.;Sept, David;Schnitzer, Jan E.;Wood, Bradford J.;Zhang, Miqin;Zheng, Gang;Farahani, Keyvan
影像学已成为医学诊断和指导患者管理的基石。一个名为图像引导药物递送（IGDD）的新领域现在将放射科学的巨大潜力与治疗的提供相结合，并有望实现个性化医疗的愿景。无论成像是用于将聚焦能量递送到载药颗粒以增强肿瘤周围的局部药物释放，还是在基于纳米颗粒的药剂的背景下调用成像来量化可以对患者进行风险分层以提高靶向药物递送效率的独特生物标志物，IGDD的首要目标是利用成像技术最大限度地提高对病变组织的有效治疗，并最大限度地减少全身药物暴露，毒性在过去的几年里，已经发表了无数的报告和评论，涵盖了IGDD技术的范围，但对识别和解决限制临床翻译的障碍的关注不够。在这一共识意见中，作为一个小组讨论了影响基于IGDD的个性化医疗临床实现的机遇和挑战，并提出了加速该领域发展的建议。
Imaging has become a cornerstone for medical diagnosis and the guidance of patient management. A new field called Image Guided Drug Delivery (IGDD) now combines the vast potential of the radiological sciences with the delivery of treatment and promises to fulfill the vision of personalized medicine. Whether imaging is used to deliver focused energy to drug-laden particles for enhanced, local drug release around tumors, or it is invoked in the context of nanoparticle-based agents to quantify distinctive biomarkers that could risk-stratify patients for improved targeted drug delivery efficiency, the overarching goal of IGDD is to use imaging to maximize effective therapy in diseased tissues and to minimize systemic drug exposure in order to reduce toxicities. Over the last several years innumerable reports and reviews covering the gamut of IGDD technologies have been published, but inadequate attention has been directed towards identifying and addressing the barriers limiting clinical translation. In this consensus opinion, the opportunities and challenges impacting the clinical realization of IGDD-based personalized medicine were discussed as a panel and recommendations were proffered to accelerate the field forward.
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影响因子：
6.7
作者：
Choi KY;Liu G;Lee S;Chen X
通讯作者：
Chen X
DOI：
10.1016/j.jconrel.2011.07.032
发表时间：
2011-12-20
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Caskey CF;Hu X;Ferrara KW
通讯作者：
Ferrara KW
影响因子：
5.3
作者：
Broadwell, RD;BakerCairns, BJ;Villegas, JC
通讯作者：
Villegas, JC
影响因子：
3.3
作者：
Bos, C;Lepetit-Coiffé, M;Moonen, CTW
通讯作者：
Moonen, CTW
影响因子：
6.2
作者：
Armstrong, Jonathan K.;Hempel, Georg;Garratty, George
通讯作者：
Garratty, George