The art of engineering viral nanoparticles.

The art of engineering viral nanoparticles.
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DOI:
10.1021/mp100225y
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发表时间:
2011-02-07
影响因子:
4.9
通讯作者:
Steinmetz NF
Steinmetz NF
中科院分区:
医学2区
文献类型:
--
作者:
Pokorski JK;Steinmetz NF

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病毒纳米技术是一个新兴的高度交叉学科领域,其中病毒纳米颗粒(VNPs)应用于电子,能源和下一代医疗器械等不同领域。VNP已经被开发为新型材料的候选物,并且通常被描述为“可编程的”,因为它们可以使用许多技术进行修饰和功能化。在这篇综述中,我们讨论的概念和方法,使VNPs工程,包括(一)生物共轭化学,(二)封装技术,(三)矿化策略,和(四)薄膜和水凝胶的发展。有了这些技术,VNPs的潜在应用仅受想象力的限制。
Viral nanotechnology is an emerging and highly interdisciplinary field in which viral nanoparticles (VNPs) are applied in diverse areas such as electronics, energy and next-generation medical devices. VNPs have been developed as candidates for novel materials, and are often described as “programmable” because they can be modified and functionalized using a number of techniques. In this review, we discuss the concepts and methods that allow VNPs to be engineered, including (i) bioconjugation chemistries, (ii) encapsulation techniques, (iii) mineralization strategies, and (iv) film and hydrogel development. With all these techniques in hand, the potential applications of VNPs are limited only by the imagination.
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