Understanding the role of milk in regulating human homeostasis in the context of the COVID-19 global pandemic.
Understanding the role of milk in regulating human homeostasis in the context of the COVID-19 global pandemic.
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了解在 COVID-19 全球大流行背景下牛奶在调节人体稳态中的作用。
DOI：
10.1016/j.tifs.2020.09.027
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发表时间：
2021-01
影响因子：
15.3
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Ren G;Cheng G;Wang J
尽管来自临床观察的数据已经直接表明，0-14岁的儿童比15 - 64岁的儿童对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的易感性更低，但由于缺乏不同年龄组之间细胞进入受体差异的生物学证据，儿童是否真的比成人更易感仍存在争议。迄今为止，关于COVID-19的研究一致表明，儿童患者的细胞因子释放综合征通常相对较轻，死亡率低于成人。有趣的是，在之前的冠状病毒疫情中也观察到了儿童症状相对较轻的类似现象，包括SARS-CoV和MERS-CoV。事实上，在生命的早期阶段，有许多机制自发地调节过度的炎症反应。牛奶作为婴幼儿的主要食物，不仅能提供婴幼儿所需的能量和营养，而且在调节免疫系统、肠道微生态和营养平衡等方面起着重要作用。本文综述了牛奶在调节人体内稳态，特别是在疾病状态下的作用。这些线索为全球COVID-19大流行期间的家庭和/或医院个人护理提供了新的见解和参考。哺乳动物后代可以通过母乳/牛乳和其他乳制品中的生物活性成分来缓解细胞因子释放综合征。牛奶中的生物活性物质可以维持体内平衡，包括免疫系统、肠道微生态和营养平衡。这些线索将在全球COVID-19大流行期间为家庭和/或医院的个人护理提供新的见解和参考。
Although data from clinical observation have directly shown that children aged 0–14 years are less susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than those who are between 15 and 64 years old, due to a lack of biological evidence of differences in cell entry receptors between age groups, it remains debatable whether children are actually less susceptible than adults. To date, studies on COVID-19 have consistently shown that pediatric patients generally have relatively milder cytokine release syndrome and lower mortality rates than adults. Interestingly, similar phenomena of relatively mild symptoms in children have been observed in previous outbreaks of coronaviruses, including SARS-CoV and MERS-CoV. In fact, in the early stage of life, there are many mechanisms that spontaneously regulate excessive inflammatory responses. Milk, as the main food of infants, not only provides necessary energy and nutrients but also plays an important role in regulating homeostasis related to the immune system, gut microecology and nutrition balance. This review discusses some roles of milk in regulating human homeostasis, especially in the disease states. These clues provide new insight and references for personal care at home and/or in the hospital during the global COVID-19 pandemic. Mammalian offspring could alleviate cytokine release syndrome through bioactive components in breast /bovine milk and other dairy products. Bioactive substances in milk can maintain homeostasis, including the immune system, intestinal microecology and nutritional balance. These clues will provide new insight and references for personal care at home and/or in the hospital during the global COVID-19 pandemic.
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影响因子：
7.3
作者：
Perdijk O;van Splunter M;Savelkoul HFJ;Brugman S;van Neerven RJJ
通讯作者：
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影响因子：
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