The science of electrical stimulation therapy for fracture healing.

The science of electrical stimulation therapy for fracture healing.
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DOI:
10.4103/0019-5413.50846
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发表时间:
2009-04
影响因子:
1
通讯作者:
Schemitsch EH
Schemitsch EH
中科院分区:
医学4区
文献类型:
--
作者:
Kuzyk PR;Schemitsch EH

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本文就电刺激促进骨折愈合的基础科学研究作一简要综述。直流电、电容耦合和电感耦合已被研究为通过成骨细胞的增殖和分化来增强骨折愈合的潜在技术。这些技术特别吸引人,因为它们为延迟骨折愈合和骨不连的临床难题提供了潜在的微创解决方案。基础科学研究已经明确表明,电刺激技术导致骨细胞增殖,并试图阐明这种骨细胞增殖发生的细胞内过程。需要进一步的基础科学和临床研究来提高这种疗法治疗骨折不愈合的有效性。
This article is a brief review of the basic science research conducted in the field of electrical stimulation for fracture healing. Direct electrical current, capacitive coupling, and inductive coupling have been studied as potential techniques to enhance fracture healing through the proliferation and differentiation of osteogenic cells. These techniques are particularly appealing as they offer a potential minimally invasive solution to the difficult clinical problem of delayed fracture healing and nonunion. Basic science studies have shown conclusively that electrical stimulation techniques lead to bone cell proliferation and have attempted to elucidate the intracellular processes by which this bone cell proliferation occurs. Further basic science and clinical research is required to enhance the effectiveness of this therapy for the treatment of fracture nonunions.
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