A model of the role of adaptation and disadaptation in olfactory receptor neurons: implications for the coding of temporal and intensity patterns in odor signals.
A model of the role of adaptation and disadaptation in olfactory receptor neurons: implications for the coding of temporal and intensity patterns in odor signals.
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嗅觉受体神经元适应和不适应作用的模型：对气味信号中时间和强度模式编码的影响。
DOI：
10.1093/chemse/19.1.71
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发表时间：
1994
期刊：
影响因子：
3.5
通讯作者：
Moore,PA
中科院分区：
文献类型：
--
作者：
Moore,PA
天然气味作为湍流羽流发生，导致化学感受器细胞处的空间和时间可变的气味信号。浓度可以在离散的气味包内广泛波动，并且单个包是非常间歇和不可预测的。化学感受器细胞显示出适应和不适应的时间动态特性，这有助于改变它们对这些波动的气味模式的反应。一个计算模型，修改从以前发表的，被用来调查，适应和适应的恢复（去适应）对模型嗅觉受体细胞在自然刺激条件下的锋电位输出的影响。模型细胞的反应特性是基于经验确定的剂量反应，适应，去适应和闪烁融合特性的外周嗅觉细胞。模型细胞的生理特性（适应和去适应率以及剂量-反应关系）可以独立地进行修改，从而可以评估每种生理特性在塑造模型细胞反应中的作用。完全适应和不适应的时间过程范围从500毫秒（快速细胞）到10秒（慢细胞）。模型细胞的刺激是在各种生物相关的流动条件下获得的定量气味羽流记录。正如预期的那样，快速适应模型细胞显示出不同的响应特性比缓慢适应模型细胞相同的时间气味配置文件。模型细胞的反应取决于它们的适应和不适应率，以及气味呈现的频率特性。这些结果表明，适应和去适应决定了特定细胞响应的浓度波动范围。因此，这些特性相当于电子学中的带通滤波器的嗅觉等效物。这种类型的过滤具有从气味信号中提取信息的含义，男人是时间和强度特征的编码。
Natural odors occur as turbulent plumes resulting in spatially and temporally variable odor signals at the chemoreceptor cells. Concentrations can fluctuate widely within discrete packets of odor and individual packets are very intermittent and unpredictable. Chemoreceptor cells display the temporally dynamic properties of adaptation and disadaptation, which serve to alter their responses to these fluctuating odor patterns. A computational model, modified from one previously published, was used to investigate, the effect of adaptation and recovery of adaptation (disadaptation) on the spike output of model olfectory receptor cells under natural stimulus conditions. The response characteristics of model cells were based upon empirically determined dose-response, adaptation, disadaptation and flicker fusion properties of peripheral olfactory cells. The physiological properties of the model cell (adaptation and disadaptation rate and the dose-response relationship) could be modified independently, allowing assessment of the role of each in shaping the responses of the model cell. Complete adaptation and disadaptation time courses ranged from 500 ms (rapid cells) to 10 s (slow cells). The stimuli for the model cells were quantified odor plume recordings obtained under a variety of biologically relevant flow conditions. As expected, the rapidly adapting model cells displayed different response characteristics than the slowly adapting model cells to identical temporal odor profiles. Responses of the model cells depended upon their adaptation and disadaptation rates, and the frequency characteristics of the odor presentation. These results indicate that adaptation and disadaptation determine the range of concentration fluctuations over which a particular cell will respond. Thus, these properties function as an olfactory equivalent of a band-pass filter in electronics. This type of filtering has implications for the extraction of information from odor signals, men is the coding of temporal and intensity features.
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适应对气味检测的影响
DOI：
--
发表时间：
1971
期刊：
影响因子：
--
作者：
B. Berglund;U. Berglund;T. Engen;T. Lindvall
通讯作者：
T. Lindvall
大龙虾嗅觉受体细胞对二元混合物的反应。
影响因子：
2.5
作者：
C. Derby;M. Girardot;P. C. Daniel
通讯作者：
P. C. Daniel
DOI：
10.3758/bf03213046
发表时间：
1967
期刊：
Perception & Psychophysics
影响因子：
--
作者：
D. Mcburney;R. Kasschau;Lloyd M. Bogart
通讯作者：
Lloyd M. Bogart
化学刺激的分布
影响因子：
10
作者：
J. Atema
通讯作者：
J. Atema
美洲白龙虾化学感应附属物的流体动力学和微观化学运动
影响因子：
3.5
作者：
P. Moore;J. Atema;G. Gerhardt
通讯作者：
G. Gerhardt