Impact of state anxiety on the interaction between threat monitoring and cognition.
Impact of state anxiety on the interaction between threat monitoring and cognition.
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DOI：
10.1016/j.neuroimage.2011.08.102
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发表时间：
2012-01-16
期刊：
影响因子：
5.7
通讯作者：
Pessoa, Luiz
中科院分区：
文献类型：
--
作者：
Choi, Jong Moon;Padmala, Srikanth;Pessoa, Luiz
威胁处理如何影响认知表现？为了研究这个问题，在目前的功能磁共振成像研究中，参与者进行了反应冲突任务（中性，一致，不一致的试验），遵循可变长度的电击预期期或相应的延迟，在此期间，他们不会被电击。延迟期由几何形状的刺激提示，指示受试者是否处于安全（无电击）或威胁（潜在电击）条件。在行为上，参与者在威胁试验期间表现出增加的反应时间干扰（不一致-中性），这种影响随着参与者的状态焦虑水平而增加。大脑成像数据进行了分析的线索和随后的目标阶段的任务。在目标相位，左前额叶表现出相互作用型反应（即，在威胁试验中增加干扰），这与状态焦虑水平呈正相关-一种描述行为模式的关系。在提示阶段，在一个区域回路中观察到对威胁与安全的更大反应，包括内侧PFC、前丘脑、丘脑和终纹/尾状核的床核，我们将其解释为参与了休克监测/预期过程。与此相反，有趣的是，在提示阶段，在与“静息状态”网络重叠的更广泛的区域中观察到对安全与威胁的更大反应。最后，一个标准的统计中介分析显示，状态焦虑分数和干扰相关的反应，在目标阶段的左前额叶之间的关系是部分介导的线索反应，在内侧PFC，一致的想法，即更多的焦虑的人在从事内侧PFC的威胁条件下有困难。总的来说，我们的研究结果表明，威胁监测损害了即将到来的干扰解决方案。此外，汇合的认知任务条件下，威胁和个体差异的状态焦虑的影响，观察到在前额叶，一个结构，这是建议是特别重要的情绪和认知之间的相互作用。
How does threat processing impact cognitive performance? To investigate this question, in the present functional magnetic resonance imaging study, participants performed a response-conflict task (neutral, congruent, and incongruent trials) that followed a variable-length shock anticipation period or a corresponding delay during which they would not be shocked. The delay period was cued by a geometric-shaped stimulus indicating whether the subject was in the safe (no shock) or threat (potential shock) condition. Behaviorally, participants showed increased reaction time interference (incongruent – neutral) during threat trials, an effect that increased as a function of state anxiety level across participants. Brain imaging data were analyzed for the cue and the subsequent target phase of the task. At the target phase, the left anterior insula exhibited interaction-type responses (i.e., increased interference during threat trials) that were positively associated with state anxiety level – a relationship that paralleled the behavioral pattern. At the cue phase, greater responses to threat vs. safe were observed in a circuit of regions, including the medial PFC, anterior insula, thalamus, and bed nucleus of the stria terminalis/caudate, which we interpreted as engaged by shock monitoring/anticipation processes. In contrast, intriguingly, greater responses to safe vs. threat at the cue phase were observed in a broader set of regions that overlapped with the “resting-state” network. Finally, a standard statistical mediation analysis revealed that the relationship between state anxiety scores and interference-related responses in the left anterior insula during the target phase was partially mediated via cue responses in the medial PFC, consistent with the idea that more anxious individuals had difficulty in engaging the medial PFC during the threat condition. Taken together, our findings suggest that threat monitoring impairs the upcoming resolution of interference. Furthermore, a confluence of effects of cognitive task condition, threat, and individual differences in state anxiety was observed in the anterior insula, a structure that is suggested to be particularly important for the interaction between emotion and cognition.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
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通讯作者：
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在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.7
作者：
Hart, Sarah J.;Green, Steven R.;Casp, Michael;Belger, Aysenil
通讯作者：
Belger, Aysenil
影响因子：
3
作者：
Bach DR;Flandin G;Friston KJ;Dolan RJ
通讯作者：
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