Evidence of decline of malaria in the general hospital of Libreville, Gabon from 2000 to 2008.
Evidence of decline of malaria in the general hospital of Libreville, Gabon from 2000 to 2008.
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DOI：
10.1186/1475-2875-8-300
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发表时间：
2009-12-17
期刊：
影响因子：
3
通讯作者：
Kombila M
中科院分区：
文献类型：
--
作者：
Bouyou-Akotet MK;Mawili-Mboumba DP;Kendjo E;Mabika-Mamfoumbi M;Ngoungou EB;Dzeing-Ella A;Pemba-Mihindou M;Ibinga E;Efame-Eya E;MCRU team;Planche T;Kremsner PG;Kombila M
据报告，在实施了新的疟疾控制战略的几个国家，疟疾传播、发病率和死亡率大幅下降。在加蓬，根据世卫组织的建议，2003年国家疟疾政策发生了变化。在加蓬首都利伯维尔，对实施前后发热儿童的疟疾发病率趋势进行了评估。2000年8月至2008年12月，在加蓬最大的公立医院的疟疾临床研究股，对11岁以下发热的儿科门诊和住院患者进行了镜检以筛查疟疾。还收集了气候数据。总共检查了28,092名发烧儿童；5岁以下儿童始终占70%以上。2000年疟疾阳性玻片的比例为45%，2008年下降到15%。在研究期间，血涂片阳性儿童的中位年龄从24(15-48)个月增加到41(21-72)个月(p<；0.01)。降雨模式对整个研究期间观察到的下降没有影响。在引入疟疾病例管理的新战略后，观察到在过去九年中发烧儿童中疟疾流行率的下降，并可能宣布流行病学变化。此外，必须将预防措施扩大到五岁以上的儿童。
Substantial decline in malaria transmission, morbidity and mortality has been reported in several countries where new malaria control strategies have been implemented. In Gabon, the national malaria policy changed in 2003, according to the WHO recommendations. The trend in malaria morbidity was evaluated among febrile children before and after their implementation in Libreville, the capital city of Gabon. From August 2000 to December 2008, febrile paediatric outpatients and inpatients, under 11 years of age, were screened for malaria by microscopic examination at the Malaria Clinical Research Unit (MCRU) located in the largest public hospital in Gabon. Climatic data were also collected. In total, 28,092 febrile children were examined; those under five years always represented more than 70%. The proportion of malaria-positive slides was 45% in 2000, and declined to 15% in 2008. The median age of children with a positive blood smear increased from 24(15-48) to 41(21-72) months over the study period (p < 0.01). Rainfall patterns had no impact on the decline observed throughout the study period. The decrease of malaria prevalence among febrile children during the last nine years is observed following the introduction of new strategies of malaria cases management, and may announce epidemiological changes. Moreover, preventive measures must be extended to children older than five years.
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影响因子：
3
作者：
Dzeing-Ella, A;Obiang, PCN;Kombila, M
通讯作者：
Kombila, M
影响因子：
3.1
作者：
Bejon, Philip;Warimwe, George;Marsh, Kevin
通讯作者：
Marsh, Kevin
DOI：
10.4269/ajtmh.2001.65.599
发表时间：
2001-11-01
影响因子：
3.3
作者：
Planche, T;Krishna, S;Kremsner, PG
通讯作者：
Kremsner, PG
DOI：
10.1016/s0035-9203(02)90345-7
发表时间：
2002-11-01
影响因子：
2.2
作者：
Borrmann, S;Binder, RK;Kremsner, PG
通讯作者：
Kremsner, PG
DOI：
10.4269/ajtmh.2007.77.418
发表时间：
2007-09-01
影响因子：
3.3
作者：
Ramharter, Michael;Schuster, Katharina;Kremsner, Peter G.
通讯作者：
Kremsner, Peter G.