Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases.
Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases.
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DOI：
10.2174/1871527311312030004
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发表时间：
2013-05-01
期刊：
影响因子：
--
通讯作者：
Arai K
中科院分区：
文献类型：
--
作者：
Maki T;Hayakawa K;Pham LD;Xing C;Lo EH;Arai K
在过去的十年中，有证据表明，在神经血管单位（NVU）内存在多种双向细胞-细胞和/或细胞-细胞外基质相互作用，NVU由神经元、神经胶质和血管细胞沿着细胞外基质组成。许多导致NVU功能障碍的中枢神经系统（CNS）疾病具有共同的特征，如胶质细胞活化/转化和血管/血脑屏障改变。这些现象表现出两种相反的作用，急性期有害，慢性期有益。这种多样的异质性可能诱导双相临床过程，即在NVU中动态协调的细胞-细胞/细胞-基质相互作用的背景下的退行性和再生过程。更深入地了解细胞水平上看似矛盾的作用对于NVU保护或再生以抑制有害的炎症反应和促进CNS损伤后的适应性重塑至关重要。本文综述了NVU双相作用的最新进展，并讨论了NVU反应与CNS疾病（如中风和其他慢性神经退行性疾病）相关的临床相关性。
In the past decade, evidence has emerged that there is a variety of bidirectional cell-cell and/or cell-extracellular matrix interactions within the neurovascular unit (NVU), which is composed of neuronal, glial, and vascular cells along with extracellular matrix. Many central nervous system (CNS) diseases, which lead to NVU dysfunction, have common features such as glial activation/transformation and vascular/blood-brain-barrier alteration. These phenomena show dual opposite roles, harmful at acute phase and beneficial at chronic phase. This diverse heterogeneity may induce biphasic clinical courses, i.e. degenerative and regenerative processes in the context of a dynamically coordinated cell-cell/cell-matrix interactions in the NVU. A deeper understanding of the seemingly contradictory actions in cellular levels is essential for NVU protection or regeneration to suppress the deleterious inflammatory reactions and promote adaptive remodeling after CNS injury. This mini-review will present an overview of recent progress in the biphasic roles of the NVU and discuss the clinical relevance of NVU responses associated with CNS diseases, such as stroke and other chronic neurodegenerative disease.
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影响因子：
9.9
作者：
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DOI：
10.1111/j.1742-4658.2009.07176.x
发表时间：
2009-09
期刊：
The FEBS journal
影响因子：
--
作者：
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