Dynamics of CD4 T Cell and Antibody Responses in COVID-19 Patients With Different Disease Severity.
Dynamics of CD4 T Cell and Antibody Responses in COVID-19 Patients With Different Disease Severity.
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DOI：
10.3389/fmed.2020.592629
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发表时间：
2020
影响因子：
3.9
通讯作者：
Aberle JH
中科院分区：
文献类型：
--
作者：
Koblischke M;Traugott MT;Medits I;Spitzer FS;Zoufaly A;Weseslindtner L;Simonitsch C;Seitz T;Hoepler W;Puchhammer-Stöckl E;Aberle SW;Födinger M;Bergthaler A;Kundi M;Heinz FX;Stiasny K;Aberle JH
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的疾病范围从轻度疾病到严重呼吸道疾病和死亡。在这项研究中，我们确定了病毒载量，抗体反应（IgM，IgG，中和）和SARS-CoV-2特异性CD 4 T细胞的动力学，通过定量435个系列呼吸道和血液样本中的这些参数，这些样本是从29名中度或重度COVID-19患者的队列中收集的，在整个住院期间或直到死亡。值得注意的是，在不同疾病严重程度的组之间，中和抗体的动力学和平台水平没有显著差异。相比之下，特异性CD 4 T细胞反应的动力学差异很大，但所有中度或重度疾病患者都产生了强烈的SARS-CoV-2特异性反应。值得注意的是，在症状发作后的第一周内，没有患者可检测到交叉反应性CD 4 T细胞，这在20-50%的未暴露个体中有描述。因此，我们的数据为抗体和CD 4 T细胞反应的动力学以及病毒载量提供了新的见解，这是理解适应性免疫在急性感染期间对抗病毒的关键，并为COVID-19免疫治疗的时机提供了线索。
Disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from mild illness to severe respiratory disease and death. In this study, we determined the kinetics of viral loads, antibody responses (IgM, IgG, neutralization) and SARS-CoV-2-specific CD4 T cells by quantifying these parameters in 435 serial respiratory and blood samples collected from a cohort of 29 COVID-19 patients with either moderate or severe disease during the whole period of hospitalization or until death. Remarkably, there was no significant difference in the kinetics and plateau levels of neutralizing antibodies among the groups with different disease severity. In contrast, the dynamics of specific CD4 T cell responses differed considerably, but all patients with moderate or severe disease developed robust SARS-CoV-2-specific responses. Of note, none of the patients had detectable cross-reactive CD4 T cells in the first week after symptom onset, which have been described in 20–50% of unexposed individuals. Our data thus provide novel insights into the kinetics of antibody and CD4 T cell responses as well as viral loads that are key to understanding the role of adaptive immunity in combating the virus during acute infection and provide leads for the timing of immune therapies for COVID-19.
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影响因子：
32.4
作者：
Ni, Ling;Ye, Fang;Dong, Chen
通讯作者：
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多器官感染和SAR的发病机理。
影响因子：
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作者：
Gu, Jiang;Gong, Encong;Zhang, Bo;Zheng, Jie;Gao, Zifen;Zhong, Yanfeng;Zou, Wanzhong;Zhan, Jun;Wang, Shenglan;Xie, Zhigang;Zhuang, Hui;Wu, Bingquan;Zhong, Haohao;Shao, Hongquan;Fang, Weigang;Gao, Dongshia;Pei, Fei;Li, Xingwang;He, Zhongpin;Xu, Danzhen;Shi, Xeying;Anderson, Virginia M;Leong, Anthony S-Y
通讯作者：
Leong, Anthony S-Y
影响因子：
5.4
作者：
Schwaiger, Julia;Aberle, Judith H.;Heinz, Franz X.
通讯作者：
Heinz, Franz X.
影响因子：
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作者：
Chandrashekar, Abishek;Liu, Jinyan;Barouch, Dan H.
通讯作者：
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作者：
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通讯作者：
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