Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment.
Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment.
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含有 Shuyusan 的血清可保护 SH-SY5Y 细胞免受皮质酮诱导的损伤。
DOI：
10.3969/j.issn.1673-5374.2013.22.005
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发表时间：
2013-08-05
影响因子：
6.1
通讯作者：
Duan D
中科院分区：
文献类型：
--
作者：
Chen L;Sun Z;Wang F;Xu C;Geng M;Chen H;Duan D
中药舒郁散的主要成分是栀子苷，已被证明可以保护SH-SY 5 Y细胞免受皮质酮诱导的损伤。用5和30 μg/mL舒郁散含药血清处理400 μmol/L皮质酮损伤的SH-SY 5 Y细胞。结果表明，舒郁散含药血清可提高SH-SY 5 Y细胞存活率，降低Bax表达，增加Bcl-2表达，显著提高脑源性神经营养因子mRNA表达，并抑制细胞凋亡。高剂量（30 μg/mL）的舒郁散含药血清作用更明显。因此，舒郁散含药血清似乎通过调节凋亡相关蛋白和脑源性神经营养因子的表达来保护SH-SY 5 Y细胞免受皮质酮诱导的损伤。此外，高剂量舒郁散含药血清对高剂量皮质酮引起的损伤具有保护作用。
The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L corticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose (30 μg/mL) Shuyusan-containing serum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing serum has a protective effect on high-dose corticosterone-induced impairment.
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影响因子：
2.7
作者：
Hurley, Laura L.;Akinfiresoye, Luli;Nwulia, Evaristus;Kamiya, Atsushi;Kulkarni, Amol A.;Tizabi, Yousef
通讯作者：
Tizabi, Yousef
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作者：
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影响因子：
25
作者：
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通讯作者：
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