Coffee Consumption May Mitigate the Risk for Acute Kidney Injury: Results From the Atherosclerosis Risk in Communities Study.
Coffee Consumption May Mitigate the Risk for Acute Kidney Injury: Results From the Atherosclerosis Risk in Communities Study.
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DOI：
10.1016/j.ekir.2022.04.091
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发表时间：
2022-07
影响因子：
6
通讯作者：
Parikh, Chirag R.
中科院分区：
文献类型：
--
作者：
Tommerdahl, Kalie L.;Hu, Emily A.;Selvin, Elizabeth;Steffen, Lyn M.;Coresh, Josef;Grams, Morgan E.;Bjornstad, Petter;Rebholz, Casey M.;Parikh, Chirag R.
咖啡是全球消费最频繁的饮品之一，并且已被发现具有多种健康益处。尽管习惯性饮用咖啡与慢性肾脏病的发病率较低有关，但咖啡与急性肾损伤（AKI）之间的关联尚未被揭示。
在社区动脉粥样硬化风险（ARIC）研究中，这是一项对14207名45至64岁成年人进行的前瞻性队列研究，通过食物频率问卷在单次访问中评估了咖啡摄入量（杯/天），并与因带有AKI相关国际疾病分类代码住院所定义的AKI发病情况进行了比较。
在ARIC研究中，在中位24年的随访期间，有1694例AKI发病病例。与不饮用咖啡相比，较高的咖啡摄入量与较低的AKI风险相关（危险比[HR]：<1杯/天：0.92[95%置信区间：0.79 - 1.08]；1杯/天：1.08[95%置信区间：0.94 - 1.24]；2至3杯/天：0.83[95%置信区间：0.72 - 0.95]；>3杯/天：0.83[95%置信区间：0.71 - 0.96]；参照组：从不饮用，P = 0.003）。在对年龄、性别、种族 - 中心、教育程度、每日总能量摄入、体力活动、吸烟、饮酒、饮食质量（终止高血压膳食疗法[DASH]评分）、收缩压（BP）、糖尿病状况、降压药使用情况、估算肾小球滤过率（eGFR）和体重指数（BMI）进行多变量调整后，咖啡各类别之间AKI风险的趋势仍然显著（P = 0.02）。
较高的咖啡摄入量与较低的AKI发病风险相关，并且可能通过饮食提供一种心脏 - 肾脏保护的机会。有必要进一步评估饮用咖啡对心脏 - 肾脏保护作用的生理机制。
Coffee is one of the most frequently consumed beverages worldwide and has been found to have a wide assortment of health benefits. Although habitual coffee consumption is associated with a lower incidence of chronic kidney disease, an association between coffee and acute kidney injury (AKI) has not yet been revealed. In the Atherosclerosis Risk in Communities (ARIC) Study, a prospective cohort study of 14,207 adults aged 45 to 64 years, coffee consumption (cups/d) was assessed at a single visit via food frequency questionnaires and compared with incident AKI defined by hospitalization with an AKI-related International Classification of Diseases code. In ARIC, there were 1694 cases of incident AKI in a median of 24 follow-up years. Higher coffee consumption was associated with lower AKI risk versus no consumption (hazard ratio [HR] <1 cup/d: 0.92 [95% CI: 0.79–1.08]; 1 cup/d: 1.08 [95% CI: 0.94–1.24]; 2 to 3 cups/d: 0.83 [95% CI: 0.72–0.95]; >3 cups/d: 0.83 [95% CI: 0.71–0.96]; reference: never, P = 0.003). Trends for AKI risk across coffee categories remained significant after multivariable adjustment for age, sex, race-center, education, total daily energy intake, physical activity, smoking, alcohol intake, diet quality (Dietary Approaches to Stop Hypertension [DASH] score), systolic blood pressure (BP), diabetes status, use of antihypertensive agents, estimated glomerular filtration rate (eGFR), and body mass index (BMI) (P = 0.02). Higher coffee intake was associated with a lower risk of incident AKI and could present an opportunity for cardiorenal protection through diet. Further evaluation of the physiological mechanisms underlying the cardiorenal protective effects of coffee consumption is necessary.
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影响因子：
--
作者：
Pavlakou P;Liakopoulos V;Eleftheriadis T;Mitsis M;Dounousi E
通讯作者：
Dounousi E
DOI：
10.12703/p6-83
发表时间：
2014
期刊：
F1000prime reports
影响因子：
--
作者：
Tögel F;Westenfelder C
通讯作者：
Westenfelder C
DOI：
10.1053/j.ajkd.2016.05.019
发表时间：
2016-12
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Rebholz CM;Crews DC;Grams ME;Steffen LM;Levey AS;Miller ER 3rd;Appel LJ;Coresh J
通讯作者：
Coresh J
影响因子：
24
作者：
Wright JD;Folsom AR;Coresh J;Sharrett AR;Couper D;Wagenknecht LE;Mosley TH Jr;Ballantyne CM;Boerwinkle EA;Rosamond WD;Heiss G
通讯作者：
Heiss G
ARIC研究中的咖啡消费和与肝有关的住院和死亡。
影响因子：
4.7
作者：
Hu EA;Lazo M;Selvin E;Hamilton JP;Grams ME;Steffen LM;Coresh J;Rebholz CM
通讯作者：
Rebholz CM