Coffee consumption and liver-related hospitalizations and deaths in the ARIC study.
Coffee consumption and liver-related hospitalizations and deaths in the ARIC study.
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ARIC研究中的咖啡消费和与肝有关的住院和死亡。
DOI：
10.1038/s41430-018-0346-0
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发表时间：
2019-08
影响因子：
4.7
通讯作者：
Rebholz CM
中科院分区：
文献类型：
--
作者：
Hu EA;Lazo M;Selvin E;Hamilton JP;Grams ME;Steffen LM;Coresh J;Rebholz CM
咖啡消费已被发现与降低慢性疾病如肝病的风险有关。然而，人们对咖啡与肝脏相关的住院和死亡之间的关系知之甚少。我们对来自社区动脉粥样硬化风险（ARIC）研究的14，208名45-64岁的参与者进行了前瞻性分析。在访视1（1987-89）和访视3（1993-95）时，使用食物频率问卷评估咖啡摄入量（杯/天）。肝脏相关住院治疗定义为通过队列监测确定的与肝脏疾病相关的任何国际疾病分类第九版（ICD-9）代码的住院治疗。肝脏相关死亡定义为在死亡证明表上任何地方列出肝脏疾病ICD-9代码的任何死亡。在中位随访24年期间，有833例肝脏相关住院事件，在中位随访25年期间，有152例肝脏相关死亡。咖啡消费量最高的参与者（≥3杯/天）更有可能是男性，白人，当前吸烟者和当前饮酒者。在我们的完全校正模型中，与从不饮酒者相比，每天饮用≥3杯咖啡与肝脏相关住院风险降低显著相关（风险比：0.79，95% CI：0.63-0.99）。在调整协变量后，咖啡消费和肝脏相关死亡之间没有显着关联。喝咖啡的人可能会降低肝脏相关住院的风险。这支持了目前的证据，即低水平和中等水平的咖啡可能对肝脏有保护作用。
Coffee consumption has been found to be associated with reduced risk of chronic conditions such as liver disease. However, less is known about the association between coffee and liver-related hospitalizations and deaths. We conducted a prospective analysis on 14,208 participants aged 45–64 years from the Atherosclerosis Risk in Communities (ARIC) study. Coffee consumption (cups/day) was assessed using food frequency questionnaires at visit 1 (1987–89) and visit 3 (1993–95). Liver-related hospitalizations were defined as a hospitalization with any International Classification of Diseases, Ninth Revision (ICD-9) code related to liver disease identified through cohort surveillance. Liver-related death was defined as any death with a liver disease ICD-9 code listed anywhere on the death certificate form. There were 833 incident cases of liver-related hospitalizations over a median follow-up of 24 years and 152 liver-related deaths over a median follow-up of 25 years. Participants who were in the highest category of coffee consumption (≥3 cups/day) were more likely to be men, whites, current smokers, and current alcohol drinkers. In our fully adjusted model, consuming ≥3 cups/day of coffee was significantly associated with a reduced risk of liver-related hospitalizations compared with never drinkers (hazard ratio: 0.79, 95% CI: 0.63–0.99). There were no significant associations between coffee consumption and liver-related deaths after adjusting for covariates. Coffee drinkers may be at lower risk for liver-related hospitalizations. This supports current evidence that low and moderate levels of coffee may be protective to the liver.
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DOI：
10.1056/nejmoa1112010
发表时间：
2012-05-17
期刊：
The New England journal of medicine
影响因子：
--
作者：
Freedman ND;Park Y;Abnet CC;Hollenbeck AR;Sinha R
通讯作者：
Sinha R
影响因子：
13.5
作者：
Xiao, Qian;Sinha, Rashmi;Graubard, Barry I.;Freedman, Neal D.
通讯作者：
Freedman, Neal D.
影响因子：
39.2
作者：
Park SY;Freedman ND;Haiman CA;Le Marchand L;Wilkens LR;Setiawan VW
通讯作者：
Setiawan VW
影响因子：
12.6
作者：
Bravi, Francesca;Bosetti, Cristina;La Vecchia, Carlo
通讯作者：
La Vecchia, Carlo
DOI：
10.1053/j.ajkd.2016.05.019
发表时间：
2016-12
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Rebholz CM;Crews DC;Grams ME;Steffen LM;Levey AS;Miller ER 3rd;Appel LJ;Coresh J
通讯作者：
Coresh J