Further validation of the affective bias test for predicting antidepressant and pro-depressant risk: effects of pharmacological and social manipulations in male and female rats.
Further validation of the affective bias test for predicting antidepressant and pro-depressant risk: effects of pharmacological and social manipulations in male and female rats.
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DOI：
10.1007/s00213-017-4687-5
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发表时间：
2017-10
影响因子：
3.4
通讯作者：
Robinson ESJ
中科院分区：
文献类型：
--
作者：
Hinchcliffe JK;Stuart SA;Mendl M;Robinson ESJ
情感偏见被假设为有助于情绪障碍的原因和治疗。我们以前已经发现，与学习和记忆相关的情感偏差，在一系列抗抑郁药和促抑郁药操作的急性治疗后观察到。本研究旨在检测在雄性和雌性Sprague道利（SD）大鼠中是否观察到相似偏倚。我们还测试了是否压力激素，皮质酮，诱导情感偏差测试（ABT）与其在抑郁症的发展中的假定作用一致的负偏差。然后，我们使用荟萃分析将我们的研究结果与Lister Hooded大鼠的数据进行比较。ABT使用受试者内研究设计，动物学习将不同的挖掘基质（在不同的日子遇到）与相同价值的食物奖励联系起来。暴露于一种基质与治疗操作（药物或环境）配对，另一种与对照条件配对。偏好测试用于测试治疗是否诱导了正或负偏倚。与之前的数据一致，雄性和雌性SD大鼠在抗抑郁药文拉法辛和社交游戏治疗后表现出相似的积极情感偏差，在FG 7142（苯二氮卓类反向激动剂）和社交应激治疗后表现出相似的消极情感偏差。皮质酮的急性治疗引起了负偏差。这些数据增加了ABT的翻译有效性，并表明皮质酮可以诱导急性治疗后的负面情感偏见，这种影响可能有助于其对情绪的长期影响。
Affective biases are hypothesised to contribute to the cause and treatment of mood disorders. We have previously found that affective biases, associated with learning and memory, are observed following acute treatments with a range of antidepressant and pro-depressant manipulations. This study aimed to test if similar biases are observed in male and female Sprague Dawley (SD) rats. We also test whether the stress hormone, corticosterone, induces a negative bias in the affective bias test (ABT) consistent with its putative role in the development of depression. We then use a meta-analysis to compare our findings with data published for the Lister Hooded rats. The ABT uses a within-subject study design where animals learn to associate distinct digging substrates, encountered on different days, with the same value food reward. Exposure to one substrate is paired with a treatment manipulation (drug or environmental) and the other with a control condition. A preference test is used to test if the treatment has induced a positive or negative bias. Consistent with previous data, both male and female SD rats exhibit similar positive affective biases following treatment with the antidepressant, venlafaxine, and social play and negative affective biases following FG 7142 (benzodiazepine inverse agonist) and social stress. Acute treatment with corticosterone induced a negative bias. These data add to the translational validity of the ABT and suggest that corticosterone can induce a negative affective bias following acute treatment, an effect which may contribute to its long-term effects on mood.
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影响因子：
17.7
作者：
Harmer, Catherine J.;O'Sullivan, Ursula;Cowen, Philip J.
通讯作者：
Cowen, Philip J.
影响因子：
3.3
作者：
Brummelte, S.;Galea, L. A. M.
通讯作者：
Galea, L. A. M.
影响因子：
10.5
作者：
Harmer, Catherine J.;Goodwin, Guy M.;Cowen, Philip J.
通讯作者：
Cowen, Philip J.
影响因子：
7.3
作者：
Hales CA;Stuart SA;Anderson MH;Robinson ES
通讯作者：
Robinson ES
影响因子：
3.4
作者：
Anderson, Michael H.;Munafo, Marcus R.;Robinson, Emma S. J.
通讯作者：
Robinson, Emma S. J.