Modelling cognitive affective biases in major depressive disorder using rodents.
Modelling cognitive affective biases in major depressive disorder using rodents.
复制标题
DOI：
10.1111/bph.12603
复制
发表时间：
2014-10
影响因子：
7.3
通讯作者：
Robinson ES
中科院分区：
文献类型：
--
作者：
Hales CA;Stuart SA;Anderson MH;Robinson ES
尽管我们对该疾病的根本病因以及抗抑郁药物如何缓解症状的了解有限，但重度抑郁症 (MDD) 影响着超过 10% 的人口。主要障碍包括缺乏复制表型各方面的良好动物模型，以及缺乏检测非人类物种抑郁样行为的测试。迄今为止，啮齿类动物的研究主要以两种类型的检测为主，这些检测旨在测试抑郁样行为：行为绝望测试，例如强迫游泳测试，以及快感缺乏测试，例如蔗糖偏好测试。这些测试在抗抑郁功效方面显示出相对较好的预测有效性，但转化有效性有限。临床研究的最新进展表明，认知情感偏差（CAB）是 MDD 的一个关键特征。通过开发神经心理学测试来提供人类 CAB 的客观测量，我们有机会使用“反向翻译”来开发和评估类似的方法是否适合使用动物研究 MDD。这种方法的第一个例子是在 2004 年报道的，其中处于假定的消极情感状态的啮齿动物在判断偏差任务中表现出悲观的选择。随后的判断偏差测试和新的情感偏差任务表明，这些类型的检测可能为使用动物研究 MDD 提供转化方法。本综述考虑了该领域的最新工作以及这些新的 CAB 动物模型的药理学和转化有效性。本文是精神病学研究中动物模型主题部分的一部分。要查看本节中的其他文章，请访问 http://dx.doi.org/10.1111/bph.2014.171.issue-20
Major depressive disorder (MDD) affects more than 10% of the population, although our understanding of the underlying aetiology of the disease and how antidepressant drugs act to remediate symptoms is limited. Major obstacles include the lack of availability of good animal models that replicate aspects of the phenotype and tests to assay depression-like behaviour in non-human species. To date, research in rodents has been dominated by two types of assays designed to test for depression-like behaviour: behavioural despair tests, such as the forced swim test, and measures of anhedonia, such as the sucrose preference test. These tests have shown relatively good predictive validity in terms of antidepressant efficacy, but have limited translational validity. Recent developments in clinical research have revealed that cognitive affective biases (CABs) are a key feature of MDD. Through the development of neuropsychological tests to provide objective measures of CAB in humans, we have the opportunity to use ‘reverse translation’ to develop and evaluate whether similar methods are suitable for research into MDD using animals. The first example of this approach was reported in 2004 where rodents in a putative negative affective state were shown to exhibit pessimistic choices in a judgement bias task. Subsequent work in both judgement bias tests and a novel affective bias task suggest that these types of assay may provide translational methods for studying MDD using animals. This review considers recent work in this area and the pharmacological and translational validity of these new animal models of CABs. This article is part of a themed section on Animal Models in Psychiatry Research. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-20
登录
查看更多内容
影响因子：
2.5
作者：
Brydges, Nichola M.;Leach, Matthew;Bateson, Melissa
通讯作者：
Bateson, Melissa
影响因子：
2.9
作者：
Burman, Oliver H. P.;Parker, Richard M. A.;Mendl, Michael T.
通讯作者：
Mendl, Michael T.
青少年压力对成年期焦虑、认知偏差和决策的影响：大鼠模型。
影响因子：
3.7
作者：
Brydges NM;Hall L;Nicolson R;Holmes MC;Hall J
通讯作者：
Hall J
影响因子：
3.4
作者：
Anderson, Michael H.;Munafo, Marcus R.;Robinson, Emma S. J.
通讯作者：
Robinson, Emma S. J.
影响因子：
2.9
作者：
Chaby LE;Cavigelli SA;White A;Wang K;Braithwaite VA
通讯作者：
Braithwaite VA