Functional Magnetic Resonance Adaptation in Visual Neuroscience

Functional Magnetic Resonance Adaptation in Visual Neuroscience
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视觉神经科学中的功能磁共振适应

DOI:
10.1515/revneuro.2008.19.4-5.363
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发表时间:
2008
影响因子:
4.1
通讯作者:
A. Kohler
A. Kohler
中科院分区:
医学3区
文献类型:
--
作者:
S. Weigelt;L. Muckli;A. Kohler

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功能磁共振成像(fMRI)是一种强有力的非侵入性工具,研究神经加工。在过去的十年里,功能磁共振成像领域出现了一种新的方法:功能磁共振成像适应。已经发现,刺激的重复导致处理该刺激的大脑区域中的fMRI信号的减少。这种现象与单细胞记录中发现的神经元适应效应有关。自从第一次实验观察到fMRI适应效应以来,该方法已被广泛应用于研究各种视觉现象,如运动,形状,物体和方向的感知。功能磁共振成像适应的最大优点是它允许在亚体素水平上评估大脑区域的功能反应概况。本综述的目的是评估用于引起fMRI适应效应的不同实验方法。我们讨论了视觉神经科学领域发表的论文,这些论文使用了fMRI适应范例。在这样做的时候,我们专注于有关实验设计,刺激呈现和影响因素,如意识和注意力的方法考虑。在这次审查的过程中,我们表明,不同的fMRI适应设计捕获异质性神经元的适应效果。随着神经元适应机制从简单的突触疲劳到复杂的网络相互作用的转变,功能磁共振适应的概念必须重新定义。
Functional magnetic resonance imaging (fMRI) is a powerful non-invasive tool to investigate neuronal processing. In the last ten years a new methodological approach in the field of fMRI has been developed: fMRI adaptation. It has been found that the repetition of a stimulus leads to a decrease of the fMRI signal in the brain region that processes this stimulus. The phenomenon has been related to neuronal adaptation effects found in single-cell recordings. Since the first experiments that observed fMRI-adaptation effects, the method has been applied extensively to study various visual phenomena, such as the perception of motion, shape, objects, and orientation. The great advantage of fMRI adaptation is that it allows assessing the functional response profile of a brain region at a subvoxel level. The purpose of the current review is to evaluate the different experimental approaches used to elicit fMRI-adaptation effects. We discuss papers published in the domain of visual neuroscience that made use of fMRI-adaptation paradigms. In doing so, we focus on methodological considerations concerning experimental design, stimulus presentation and influencing factors such as awareness and attention. In the course of this review, we show that different fMRI-adaptation designs capture heterogeneous neuronal adaptation effects. As the picture of the mechanisms underlying neuronal adaptation changes from simple synaptic fatigue to complex network interactions, the concept of fMRI adaptation has to be redefined.
梭状回的启动效应:第二次呈现之后神经活动的变化。
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发表时间: 2005
期刊: Cerebral cortex (New York, N.Y. : 1991)
影响因子: --
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