Effect of combining anesthetics in neonates on long-term cognitive function.
Effect of combining anesthetics in neonates on long-term cognitive function.
复制标题
在新生儿中结合麻醉剂对长期认知功能的影响。
DOI：
10.1016/j.ijdevneu.2014.06.016
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Sall JW
中科院分区：
文献类型：
--
作者：
Lee BH;Hazarika OD;Quitoriano GR;Lin N;Leong J;Brosnan H;Chan JT;May LD;Yu D;Alkhamisi A;Stratmann G;Sall JW
随着越来越多的证据表明婴儿时期的麻醉暴露会影响认知发展，了解不同的麻醉剂和组合如何改变长期记忆是很重要的。对神经元死亡的研究表明，复合麻醉剂会增加神经元损伤的程度。然而，与使用单一麻醉剂相比，同时使用复合麻醉剂对认知结果的影响尚不清楚。出生后第7天，给雄性大鼠单独使用七氟醚或七氟醚与一氧化二氮以1的最低肺泡浓度联合给药4h。成年后用强迫交替T迷宫、社会再认和特定背景物体再认任务评估行为。在强迫交替T迷宫测试中，暴露于任何一种麻醉剂的动物都没有受到损害，并具有完整的社会认知度。然而，接受复合麻醉剂治疗的受试者在物体识别任务中表现出缺陷，而只接受七氟醚治疗的受试者没有受到影响。与单独使用七氟醚相比，七氟醚和一氧化二氮复合麻醉剂导致了不同的行为结果，这表明同时使用多种药物可能独特地影响早期神经和认知发育，并可能影响联想记忆。
With growing evidence that anesthesia exposure in infancy affects cognitive development, it is important to understand how distinct anesthetic agents and combinations can alter long-term memory. Investigations of neuronal death suggest that combining anesthetic agents increases the extent of neuronal injury. However, it is unclear how the use of simultaneously combined anesthetics affects cognitive outcome relative to the use of a single agent. Postnatal day (P)7 male rats were administered either sevoflurane as a single agent or the combined delivery of sevoflurane with nitrous oxide at 1 Minimum Alveolar Concentration for 4 h. Behavior was assessed in adulthood using the forced alternating T-maze, social recognition, and context-specific object recognition tasks. Animals exposed to either anesthetic were unimpaired in the forced alternating T-maze test and had intact social recognition. Subjects treated with the combined anesthetic displayed a deficit, however, in the object recognition task, while those treated with sevoflurane alone were unaffected. A combined sevoflurane and nitrous oxide anesthetic led to a distinct behavioral outcome compared with sevoflurane alone, suggesting that the simultaneous use of multiple agents may uniquely influence early neural and cognitive development and potentially impacts associative memory.
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DOI：
10.1073/pnas.0705273104
发表时间：
2007-10-09
影响因子：
11.1
作者：
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通讯作者：
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