Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat.
Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat.
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影响大鼠性别和性腺的气味化合物和 3 种雄性信息素
DOI：
10.1093/chemse/bjn028
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发表时间：
2008-09
期刊：
影响因子：
3.5
通讯作者：
Feng ZY
中科院分区：
文献类型：
--
作者：
Zhang JX;Sun L;Zhang JH;Feng ZY
本研究旨在鉴定褐家鼠（Rattus norvegicus）的性信息素。采用气相色谱-质谱法（GC - ms）对大鼠包皮腺和排尿的挥发物和半挥发物进行了表征，并通过其GC面积（丰度）和GC面积百分比（相对丰度）进行了定量分析。尽管除4-庚酮和苯酚外，检测到的所有化合物都是雄性和雌性共有的，但其中一些性别共有的化合物的数量表现出性别二态性，并在性腺切除术后减少。因此，这些化合物可能是性信息素。其中包皮腺中的角鲨烯、尿液中的2-庚酮和4-乙基苯酚是3种主要化合物。它们在雄性中更丰富，可以通过阉割来抑制。将这三种化合物中的任何一种（浓度高于其在男性尿液中的生理水平）添加到阉割的男性尿液（CMU）中，都增加了CMU对性幼稚的女性的吸引力。在CMU中加入这3种物质（正常男性尿液中的含量）会显著增加CMU对女性的吸引力。然而，这种组合并不能完全恢复雌性对完整雄性尿液的偏好，这表明一些其他微量化合物，如4-庚酮和苯酚，也可能在性吸引力方面发挥一定作用。因此，角鲨烯、2-庚酮和4-乙基苯酚确实是大鼠体内的雄性信息素分子。我们的研究还表明，E、E-β-法尼烯和E-α-法尼烯在雌性中含量均高于雄性，可能是雌性信息素。
This study was aimed at identifying sex pheromones of the rat (Rattus norvegicus). We characterized the volatiles and semivolatiles of rat preputial gland and voided urine by using gas chromatography–mass spectrometry (GC–MS) and quantified them by their GC areas (abundances) and percentage of GC areas (relative abundances). Although all the compounds other than 4-heptanone and phenol detected were shared by males and females, the quantities for some of these sex-common compounds exhibited sexual dimorphism and decreased with gonadectomy. Thus, these compounds might be sex pheromones. Among them, squalene from preputial glands and 2-heptanone and 4-ethyl phenol from urine were 3 major compounds. They were richer in males and could be suppressed by castration. Adding any of the 3 compounds (at a concentration higher than its physiological level in male urine) to castrated male urine (CMU) increased the attractiveness of CMU to sex-naive females. Adding the 3 together (at the levels in normal male urine) to CMU significantly increased the attractiveness of CMU to females. However, such combination did not fully restore females' preference for urine from intact males, suggesting that some other trace compounds such as 4-heptanone and phenol might also play some roles in sex attractiveness. Thus, squalene, 2-heptanone, and 4-ethyl phenol were indeed male pheromone molecules in rats. Our study also indicates that E,E-β-farnesene and E-α-farnesene, both richer in females than males, might be putative female pheromones.
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影响因子：
3.5
作者：
Kashiwayanagi, M
通讯作者：
Kashiwayanagi, M
影响因子：
2.3
作者：
NATYNCZUK, SE;MACDONALD, DW;TATTERSALL, FH
通讯作者：
TATTERSALL, FH
影响因子：
2.5
作者：
JEMIOLO, B;ALBERTS, J;NOVOTNY, M
通讯作者：
NOVOTNY, M
影响因子：
64.8
作者：
Lin, DY;Zhang, SZ;Katz, LC
通讯作者：
Katz, LC
影响因子：
2.9
作者：
Brouette-Lahlou, I;Godinot, F;Vernet-Maury, E
通讯作者：
Vernet-Maury, E