Prediction of Invasive Breast Cancer Using Mass Characteristic Frequency and Elasticity in Correlation with Prognostic Histologic Features and Immunohistochemical Biomarkers.
Prediction of Invasive Breast Cancer Using Mass Characteristic Frequency and Elasticity in Correlation with Prognostic Histologic Features and Immunohistochemical Biomarkers.
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DOI：
10.1016/j.ultrasmedbio.2021.03.039
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发表时间：
2021-08
影响因子：
2.9
通讯作者：
Alizad A
中科院分区：
文献类型：
--
作者：
Gu J;Polley EC;Boughey JC;Fazzio RT;Fatemi M;Alizad A
This purpose of this study is to correlate a new shear wave elastography (SWE) parameter, mass characteristic frequency (fmass), and other elasticity measure with the prognostic histological factors and immunohistochemical (IHC) biomarkers for the evaluation of heterogeneous breast carcinomas. The new parameter, fmass , first introduced in this paper, is defined as the ratio of the averaged minimum shear wave speed taken spatially within ROIs to the largest mass dimension. 264 biopsy-proven breast cancerous masses were included in this study. Mean (Emean), maximum (Emax), minimum (Emin) shear wave elasticity and standard deviation (Esd) of shear wave elasticity were found significantly correlated with tumor size, axillary lymph node (ALN) status, histological subtypes and IHC subtypes. The areas under the curve (AUCs) for the ALN prediction are 0.73 (0.95 CI 0.67-0.79) and 0.75 (0.95 CI .64-0.81) for the combination of Emean with BI-RADS score and Emax with BI-RADS score, respectively. fmass was significantly correlated with the presence of calcifications, ALN status, histological grade, the expressions of IHC biomarkers and IHC subtypes. To conclude, poor prognostic factors were associated with high shear wave elasticity values and low mass characteristic frequency value. Therefore, SWE provides valuable information that may help with prediction of breast cancer invasiveness.
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影响因子：
3.8
作者：
Evans, Andrew;Rauchhaus, Petra;Whelehan, Patsy;Thomson, Kim;Purdie, Colin A.;Jordan, Lee B.;Michie, Caroline O.;Thompson, Alastair;Vinnicombe, Sarah
通讯作者：
Vinnicombe, Sarah
DOI：
10.1186/bcr2787
发表时间：
2010
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Evans A;Whelehan P;Thomson K;McLean D;Brauer K;Purdie C;Jordan L;Baker L;Thompson A
通讯作者：
Thompson A
影响因子：
4.6
作者：
Fenner J;Stacer AC;Winterroth F;Johnson TD;Luker KE;Luker GD
通讯作者：
Luker GD
影响因子：
45.3
作者：
Cobleigh, MA;Vogel, CL;Slamon, DJ
通讯作者：
Slamon, DJ
影响因子：
19.7
作者：
Evans, Andrew;Whelehan, Patsy;Thompson, Alastair
通讯作者：
Thompson, Alastair